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タイトル: | Foveal Damage Due to Subfoveal Hemorrhage Associated with Branch Retinal Vein Occlusion. |
著者: | Muraoka, Yuki Tsujikawa, Akitaka Takahashi, Ayako Iida, Yuto Murakami, Tomoaki Ooto, Sotaro Suzuma, Kiyoshi Uji, Akihito Yoshimura, Nagahisa |
著者名の別形: | 大音, 壮太郎 鈴間, 潔 宇治, 彰人 吉村, 長久 |
発行日: | 14-Dec-2015 |
出版者: | Public Library of Science |
誌名: | PLOS ONE |
巻: | 10 |
号: | 12 |
論文番号: | e0144894 |
抄録: | To investigate the functional and morphologic prognoses of eyes with subfoveal hemorrhage from acute branch retinal vein occlusion (BRVO), and to examine the effect of intravitreal ranibizumab injection (IVR) on these prognoses, we assessed 81 eyes with acute BRVO, of which 38 did not receive IVR [IVR(-) group], and 43 were treated with IVR [IVR(+) group] for macular edema. The foveal morphologic changes were examined via optical coherence tomography (OCT). At initial examination, 63 eyes exhibited subfoveal hemorrhage. At final examination, the defect lengths in the foveal external limiting membrane (ELM) and ellipsoid lines in these eyes were longer, and final VA was significantly poorer, compared with eyes without subfoveal hemorrhage. In comparisons between the final measurements in eyes with subfoveal hemorrhage in the IVR(-) and IVR(+) groups, while there were no differences in initial ocular conditions, final VA was significantly better in the IVR(+) group. The defects in the ELM and ellipsoid lines in the IVR(+) group were shorter than those of the IVR(-) group (p = 0.002 in both). Final VA was correlated with the defect lengths of foveal ELM and ellipsoid lines in both the IVR(-) and IVR(+) groups (both p < 0.001). In addition, the defect lengths of foveal ELM and ellipsoid lines were closely correlated with the duration of subfoveal hemorrhage (both p < 0.001). BRVO-associated subfoveal hemorrhage caused damage to the foveal photoreceptors, and visual dysfunction. However, IVR improved these prognoses, by accelerating the absorption of the subfoveal hemorrhage. |
著作権等: | © 2015 Muraoka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
URI: | http://hdl.handle.net/2433/214517 |
DOI(出版社版): | 10.1371/journal.pone.0144894 |
PubMed ID: | 26661582 |
出現コレクション: | 学術雑誌掲載論文等 |
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