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Title: Perforation of intramural gastric metastasis during preoperative chemotherapy in a patient with thoracic esophageal squamous cell carcinoma
Authors: Okumura, Tomoyuki
Shimada, Yutaka
Hojo, Shozo
Sekine, Shinich
Hirano, Katsuhisa
Moriyama, Makoto
Miwa, Shigeharu
Nagata, Takuya
Tsukada, Kazuhiro
Author's alias: 嶋田, 裕
Keywords: Esophageal cancer
Intramural gastric metastasis
Neoadjuvant chemotherapy
Issue Date: 2015
Publisher: Elsevier Ltd
Journal title: International Journal of Surgery Case Reports
Volume: 17
Start page: 23
End page: 27
Abstract: [Introduction] Perforation of intramural metastasis to the stomach (IMS) from esophageal cancer during chemotherapy has not been reported. [Presentation of case] A 68-year-old male consulted our hospital due to appetite loss. He was diagnosed with advanced esophageal squamous cell carcinoma in the lower thoracic esophagus along with a large IMS in the upper stomach. The patient received preoperative chemotherapy of docetaxel, cisplatin, and 5-fluorouracil (DCF). During the second cycle of DCF, he had upper abdominal pain and was diagnosed with gastric perforation. Omental implantation repair for the perforation, peritoneal drainage, tube-gastrostomy, and tube-jejunostomy were performed. At 24 days after emergency surgery, he underwent thoracoscopic radical esophagectomy with total gastrectomy and reconstruction with colonic interposition. Pathological findings in the esophagus demonstrated complete replacement of the tumor by fibrosis. The gastric tumor was replaced by scar tissue with multinucleated giant cells along with a small amount of viable cancer cells. The patient was alive and healthy at 14 months after the radical operation, without tumor recurrence. [Discussion] The gastric perforation occurred due to rapid regression of the IMS which had involved the whole gastric wall before chemotherapy. Close monitoring to detect rapid tumor shrinkage during chemotherapy in patients with IMS may be warranted. A two-step operation was proposed to achieve safe curative treatment in patients with perforation of IMS during preoperative chemotherapy. [Conclusion] We describe the first reported case of a patient with esophageal squamous cell carcinoma who showed perforation of IMS during preoperative chemotherapy.
Rights: © 2015 The Authors. Published by Elsevier Ltd. on behalf of IJS Publishing Group Ltd. This is an open access article under the CC BY-NC-ND license (
DOI(Published Version): 10.1016/j.ijscr.2015.10.024
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