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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| cas.12924.pdf | 511.8 kB | Adobe PDF | 見る/開く |
| タイトル: | The Wnt7's Tale: A story of an orphan who finds her tie to a famous family |
| 著者: | Noda, Makoto   https://orcid.org/0000-0002-7340-6066 (unconfirmed)Vallon, Mario Kuo, Calvin J. |
| 著者名の別形: | 野田, 亮 |
| キーワード: | Angiogenesis Gpr124 Reck Wnt7a/b Zebrafish |
| 発行日: | May-2016 |
| 出版者: | John Wiley & Sons Australia, Ltd |
| 誌名: | Cancer Science |
| 巻: | 107 |
| 号: | 5 |
| 開始ページ: | 576 |
| 終了ページ: | 582 |
| 抄録: | The transformation suppressor gene RECK was isolated by cDNA expression cloning (1998), and GPR124/TEM5 was detected as a tumor endothelial marker by differential screening (2000). The importance of Wnt7a/b and Gpr124 in brain angiogenesis was demonstrated by reverse genetics in mice (2008-2010). A series of recent studies using genetically engineered mice and zebrafish as well as luciferase reporter assays in cultured cells led to the discovery of functional interactions among Reck, Gpr124, and Wnt7a/b in triggering canonical Wnt signaling with relevance to embryonic brain angiogenesis and blood-brain barrier formation. |
| 著作権等: | © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| URI: | http://hdl.handle.net/2433/215161 |
| DOI(出版社版): | 10.1111/cas.12924 |
| PubMed ID: | 26934061 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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