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Title: Enteral supplementation with glutamine, fiber, and oligosaccharide modulates incretin and glucagon-like peptide-2 secretion
Authors: Joo, Erina
Muraoka, Atsushi
Hamasaki, Akihiro
Harada, Norio  kyouindb  KAKEN_id
Yamane, Shunsuke  kyouindb  KAKEN_id
Kondo, Yaeko
Suzuki, Kazuyo  kyouindb  KAKEN_id  orcid (unconfirmed)
Nasteska, Daniela
Shibue, Kimitaka
Harada, Takanari
Iwasaki, Kanako
Tsuji, Hidemi
Shide, Kenichiro
Inagaki, Nobuya  kyouindb  KAKEN_id
Author's alias: 原田, 範雄
山根, 俊介
稲垣, 暢也
Keywords: Glucagon-like peptide-2
Issue Date: May-2015
Publisher: Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd
Journal title: Journal of Diabetes Investigation
Volume: 6
Issue: 3
Start page: 302
End page: 308
Abstract: Aims/Introduction: A dietary supplementation product enriched with glutamine, dietary fiber and oligosaccharide (GFO) is widely applied for enteral nutrition support in Japan. The aim of the present study was to evaluate the effects of GFO ingestion on secretion of incretins, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and glucagon-like peptide-2 (GLP-2). Materials and Methods: We carried out a cross-over study involving 20 healthy Japanese volunteers. The participants received GFO or 17 g of glucose, the equivalent carbohydrate in GFO as the control. Plasma glucose, serum insulin, and plasma total GIP, total GLP-1 and total GLP-2 levels during GFO or glucose loading were determined. Results: GFO loading produced significantly higher plasma GLP-1 levels at 30 min and 60 min, area under the curve-GLP-1 value, and area under the curve-GLP-2 value after administration compared with those by glucose loading. In contrast, plasma GIP levels at both 30 and 60 min, and area under the curve-GIP value after glucose loading were significantly higher than those after GFO loading. Conclusions: These results show that GFO ingestion stimulates GLP-1 and GLP-2 secretion, and reduces GIP secretion compared with glucose ingestion. Therefore, GFO could have an intestinotrophic effect as well as an ameliorating effect on metabolic disorders through modification of release of gut hormones.
Rights: © 2014 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
DOI(Published Version): 10.1111/jdi.12289
Appears in Collections:Journal Articles

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