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タイトル: | Enteral supplementation with glutamine, fiber, and oligosaccharide modulates incretin and glucagon-like peptide-2 secretion |
著者: | Joo, Erina Muraoka, Atsushi Hamasaki, Akihiro Harada, Norio Yamane, Shunsuke Kondo, Yaeko Suzuki, Kazuyo https://orcid.org/0000-0001-5716-5242 (unconfirmed) Nasteska, Daniela Shibue, Kimitaka Harada, Takanari Iwasaki, Kanako Tsuji, Hidemi Shide, Kenichiro Inagaki, Nobuya |
著者名の別形: | 原田, 範雄 山根, 俊介 稲垣, 暢也 |
キーワード: | Glucagon-like peptide-2 Incretin Oligosaccharide |
発行日: | May-2015 |
出版者: | Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd |
誌名: | Journal of Diabetes Investigation |
巻: | 6 |
号: | 3 |
開始ページ: | 302 |
終了ページ: | 308 |
抄録: | Aims/Introduction: A dietary supplementation product enriched with glutamine, dietary fiber and oligosaccharide (GFO) is widely applied for enteral nutrition support in Japan. The aim of the present study was to evaluate the effects of GFO ingestion on secretion of incretins, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and glucagon-like peptide-2 (GLP-2). Materials and Methods: We carried out a cross-over study involving 20 healthy Japanese volunteers. The participants received GFO or 17 g of glucose, the equivalent carbohydrate in GFO as the control. Plasma glucose, serum insulin, and plasma total GIP, total GLP-1 and total GLP-2 levels during GFO or glucose loading were determined. Results: GFO loading produced significantly higher plasma GLP-1 levels at 30 min and 60 min, area under the curve-GLP-1 value, and area under the curve-GLP-2 value after administration compared with those by glucose loading. In contrast, plasma GIP levels at both 30 and 60 min, and area under the curve-GIP value after glucose loading were significantly higher than those after GFO loading. Conclusions: These results show that GFO ingestion stimulates GLP-1 and GLP-2 secretion, and reduces GIP secretion compared with glucose ingestion. Therefore, GFO could have an intestinotrophic effect as well as an ameliorating effect on metabolic disorders through modification of release of gut hormones. |
著作権等: | © 2014 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
URI: | http://hdl.handle.net/2433/215184 |
DOI(出版社版): | 10.1111/jdi.12289 |
PubMed ID: | 25969715 |
出現コレクション: | 学術雑誌掲載論文等 |
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