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dc.contributor.authorSokai, Akihikoja
dc.contributor.authorHanda, Tomohiroja
dc.contributor.authorTanizawa, Kiminobuja
dc.contributor.authorOga, Toruja
dc.contributor.authorUno, Kazukoja
dc.contributor.authorTsuruyama, Tatsuakija
dc.contributor.authorKubo, Takeshija
dc.contributor.authorIkezoe, Koheija
dc.contributor.authorNakatsuka, Yoshinarija
dc.contributor.authorTanimura, Kazuyaja
dc.contributor.authorMuro, Shigeoja
dc.contributor.authorHirai, Toyohiroja
dc.contributor.authorNagai, Sonokoja
dc.contributor.authorChin, Kazuoja
dc.contributor.authorMishima, Michiakija
dc.contributor.alternative半田, 知宏ja
dc.contributor.alternative谷澤, 公伸ja
dc.contributor.alternative小賀, 徹ja
dc.contributor.alternative鶴山, 竜昭ja
dc.contributor.alternative久保, 武ja
dc.contributor.alternative室, 繁郎ja
dc.contributor.alternative平井, 豊博ja
dc.contributor.alternative陳, 和夫ja
dc.contributor.alternative三嶋, 理晃ja
dc.description.abstractBackground: Matrix metalloproteinases (MMPs) are believed to be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF), and MMP-7 has been described as a useful biomarker for IPF. However, little is known regarding the significance of MMP-10 as a biomarker for IPF. Methods: This observational cohort study included 57 patients with IPF. Serum MMPs were comprehensively measured in all patients, and the relationships between these markers and both disease severity and prognosis were evaluated. Bronchoalveolar lavage fluid (BALF) MMP-7 and -10 levels were measured in 19 patients to investigate the correlation between these markers and their corresponding serum values. Immunohistochemical staining for MMP-10 was also performed in IPF lung tissue. Results: Serum MMP-7 and -10 levels correlated significantly with both the percentage of predicted forced vital capacity (ρ = -0.31, p = 0.02 and ρ = -0.34, p < 0.01, respectively) and the percentage of predicted diffusing capacity of the lung for carbon monoxide (ρ = -0.32, p = 0.02 and ρ = -0.43, p < 0.01, respectively). BALF MMP-7 and -10 levels correlated with their corresponding serum concentrations. Only serum MMP-10 predicted clinical deterioration within 6 months and overall survival. In IPF lungs, the expression of MMP-10 was enhanced and localized to the alveolar epithelial cells, macrophages, and peripheral bronchiolar epithelial cells. Conclusions: MMP-10 may be a novel biomarker reflecting both disease severity and prognosis in patients with IPF.ja
dc.publisherBioMed Central Ltd.ja
dc.rights© 2015 Sokai et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.ja
dc.subjectMatrix metalloproteinase-10ja
dc.subjectIdiopathic pulmonary fibrosisja
dc.titleMatrix metalloproteinase-10: A novel biomarker for idiopathic pulmonary fibrosisja
dc.type.niitypeJournal Articleja
dc.identifier.jtitleRespiratory Researchja
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