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dc.contributor.author | De Almeida, Glícia Maria | en |
dc.contributor.author | Yamamoto, Mako | en |
dc.contributor.author | Morioka, Yoko | en |
dc.contributor.author | Ogawa, Shuichiro | en |
dc.contributor.author | Matsuzaki, Tomoko | en |
dc.contributor.author | Noda, Makoto | en |
dc.contributor.alternative | 松﨑, 朋子 | ja |
dc.contributor.alternative | 野田, 亮 | ja |
dc.date.accessioned | 2016-07-12T01:51:28Z | - |
dc.date.available | 2016-07-12T01:51:28Z | - |
dc.date.issued | 2015-12-11 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2433/215933 | - |
dc.description | A Corrigendum to this article was published on 04 March 2016. This article has been updated. | en |
dc.description.abstract | Extracellular matrix (ECM) is known to play several important roles in vascular development, although the molecular mechanisms behind these remain largely unknown. RECK, a tumor suppressor downregulated in a wide variety of cancers, encodes a membrane-anchored matrix-metalloproteinase-regulator. Mice lacking functional Reck die in utero, demonstrating its importance for mammalian embryogenesis; however, the underlying causes of mid-gestation lethality remain unclear. Using Reck conditional knockout mice, we have now demonstrated that the lack of Reck in vascular mural cells is largely responsible for mid-gestation lethality. Experiments using cultured aortic explants further revealed that Reck is essential for at least two events in sprouting angiogenesis; (1) correct association of mural and endothelial tip cells to the microvessels and (2) maintenance of fibronectin matrix surrounding the vessels. These findings demonstrate the importance of appropriate cell-cell interactions and ECM maintenance for angiogenesis and the involvement of Reck as a critical regulator of these events. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | en |
dc.rights | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en |
dc.title | Critical roles for murine Reck in the regulation of vascular patterning and stabilization | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Scientific Reports | en |
dc.identifier.volume | 5 | - |
dc.relation.doi | 10.1038/srep17860 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 17860 | - |
dc.identifier.pmid | 26658478 | - |
dc.relation.url | https://doi.org/10.1038/srep20749 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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