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タイトル: | Effects of age and blood pressure on the retinal arterial wall, analyzed using adaptive optics scanning laser ophthalmoscopy |
著者: | Arichika, Shigeta Uji, Akihito Ooto, Sotaro Muraoka, Yuki Yoshimura, Nagahisa |
著者名の別形: | 宇治, 彰人 大音, 壮太郎 村岡, 勇貴 吉村, 長久 |
発行日: | 20-Jul-2015 |
出版者: | Nature Publishing Group |
誌名: | Scientific Reports |
巻: | 5 |
論文番号: | 12283 |
抄録: | The wall-to-lumen ratio (WLR) of the vasculature is a promising early marker of retinal microvascular changes. Recently, adaptive optics scanning laser ophthalmoscopy (AOSLO) enabled direct and noninvasive visualization of the arterial wall. Using AOSLO, we analyzed the correlation between age and WLR in 51 normal subjects. In addition, correlations between blood pressure and WLR were analyzed in 73 subjects (51 normal subjects and 22 hypertensive patients). WLR showed a strong correlation with age (r=0.68, P<0.0001), while outer diameter and inner diameter did not show significant correlation with age in the normal group (r=0.13, P=0.36 and r=0.12, P=0.41, respectively). In the normal and hypertensive groups, WLR showed a strong correlation with systolic and diastolic blood pressure (r=0.60, P<0.0001 and r=0.65, P<0.0001, respectively). In conclusion, AOSLO provided noninvasive and reproducible arterial measurements. WLR is an early marker of morphological changes in the retinal arteries due to age and blood pressure. |
著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/216113 |
DOI(出版社版): | 10.1038/srep12283 |
PubMed ID: | 26192115 |
出現コレクション: | 学術雑誌掲載論文等 |
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