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j.stemcr.2016.05.015.pdf | 3.17 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Sakano, Daisuke | en |
dc.contributor.author | Choi, Sungik | en |
dc.contributor.author | Kataoka, Masateru | en |
dc.contributor.author | Shiraki, Nobuaki | en |
dc.contributor.author | Uesugi, Motonari | en |
dc.contributor.author | Kume, Kazuhiko | en |
dc.contributor.author | Kume, Shoen | en |
dc.contributor.alternative | 上杉, 志成 | ja |
dc.date.accessioned | 2016-08-22T07:37:33Z | - |
dc.date.available | 2016-08-22T07:37:33Z | - |
dc.date.issued | 2016-07-12 | - |
dc.identifier.issn | 2213-6711 | - |
dc.identifier.uri | http://hdl.handle.net/2433/216336 | - |
dc.description.abstract | Understanding the molecular mechanisms that regulate β cell mass and proliferation is important for the treatment of diabetes. Here, we identified domperidone (DPD), a dopamine D2 receptor (DRD2) antagonist that enhances β cell mass. Over time, islet β cell loss occurs in dissociation cultures, and this was inhibited by DPD. DPD increased proliferation and decreased apoptosis of β cells through increasing intracellular cAMP. DPD prevented β cell dedifferentiation, which together highly contributed to the increased β cell mass. DRD2 knockdown phenocopied the effects of domperidone and increased the number of β cells. Drd2 overexpression sensitized the dopamine responsiveness of β cells and increased apoptosis. Further analysis revealed that the adenosine agonist 5′-N-ethylcarboxamidoadenosine, a previously identified promoter of β cell proliferation, acted with DPD to increase the number of β cells. In humans, dopamine also modulates β cell mass through DRD2 and exerts an inhibitory effect on adenosine signaling. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2016 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
dc.title | Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Stem cell reports | en |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 95 | - |
dc.identifier.epage | 109 | - |
dc.relation.doi | 10.1016/j.stemcr.2016.05.015 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 27373926 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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