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タイトル: Tumor growth suppression by the combination of nanobubbles and ultrasound
著者: Suzuki, Ryo
Oda, Yusuke
Omata, Daiki
Nishiie, Norihito
Koshima, Risa
Shiono, Yasuyuki
Sawaguchi, Yoshikazu
Unga, Johan
Naoi, Tomoyuki
Negishi, Yoichi
Kawakami, Shigeru
Hashida, Mitsuru  kyouindb  KAKEN_id
Maruyama, Kazuo
著者名の別形: 橋田, 充
キーワード: Cancer immunity
cavitation
hyperthermia
nanobubbles
ultrasound
発行日: Mar-2016
出版者: Wiley-Blackwell
誌名: Cancer Science
巻: 107
号: 3
開始ページ: 217
終了ページ: 223
抄録: We previously developed novel liposomal nanobubbles (Bubble liposomes [BL]) that oscillate and collapse in an ultrasound field, generating heat and shock waves. We aimed to investigate the feasibility of cancer therapy using the combination of BL and ultrasound. In addition, we investigated the anti-tumor mechanism of this cancer therapy. Colon-26 cells were inoculated into the flank of BALB/c mice to induce tumors. After 8 days, BL or saline was intratumorally injected, followed by transdermal ultrasound exposure of tumor tissue (1 MHz, 0–4 W/cm[2], 2 min). The anti-tumor effects were evaluated by histology (necrosis) and tumor growth. In vivo cell depletion assays were performed to identify the immune cells responsible for anti-tumor effects. Tumor temperatures were significantly higher when treated with BL + ultrasound than ultrasound alone. Intratumoral BL caused extensive tissue necrosis at 3–4 W/cm[2] of ultrasound exposure. In addition, BL + ultrasound significantly suppressed tumor growth at 2–4 W/cm[2]. In vivo depletion of CD8[+] T cells (not NK or CD4[+] T cells) completely blocked the effect of BL + ultrasound on tumor growth. These data suggest that CD8[+] T cells play a critical role in tumor growth suppression. Finally, we concluded that BL + ultrasound, which can prime the anti-tumor cellular immune system, may be an effective hyperthermia strategy for cancer treatment.
著作権等: © 2015 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
URI: http://hdl.handle.net/2433/216365
DOI(出版社版): 10.1111/cas.12867
出現コレクション:学術雑誌掲載論文等

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