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タイトル: | Morphogenesis of the Inner Ear at Different Stages of Normal Human Development |
著者: | Toyoda, Saki Shiraki, Naoto Yamada, Shigehito https://orcid.org/0000-0002-8194-6927 (unconfirmed) Uwabe, Chigako Imai, Hirohiko Matsuda, Tetsuya https://orcid.org/0000-0002-2339-1521 (unconfirmed) Yoneyama, Akio Takeda, Tohoru Takakuwa, Tetsuya https://orcid.org/0000-0002-9660-9384 (unconfirmed) |
著者名の別形: | 山田, 重人 松田, 哲也 高桑, 徹也 |
キーワード: | inner ear membranous labyrinth three-dimensional kinetics human embryo MR imaging phase-contrast X-ray CT |
発行日: | Dec-2015 |
出版者: | Blackwell Publishing Inc. |
誌名: | The Anatomical Record |
巻: | 298 |
号: | 12 |
開始ページ: | 2081 |
終了ページ: | 2090 |
抄録: | This study examined the external morphology and morphometry of the human embryonic inner ear membranous labyrinth and documented its three-dimensional position in the developing embryo using phase-contrast X-ray computed tomography and magnetic resonance imaging. A total of 27 samples between Carnegie stage (CS) 17 and the postembryonic phase during trimester 1 (approximately 6-10 weeks after fertilization) were included. The otic vesicle elongated along the dorso-ventral axis and differentiated into the end lymphatic appendage and cochlear duct (CD) at CS 17. The spiral course of the CD began at CS18, with anterior and posterior semicircular ducts (SDs) forming prominent circles with a common crus. The spiral course of the CD comprised more than two turns at the postembryonic phase, at which time the height of the CD was evident. A linear increase was observed in the length of anterior, posterior, and lateral SDs, in that order, and the length of the CD increased exponentially over the course of development. Bending in the medial direction was observed between the cochlear and vestibular parts from the latero-caudal view, with the angle decreasing during development. The position of the inner ear was stable throughout the period of observation on the lateral to ventral side of the rhombencephalon, caudal to the pontine flexure, and adjacent to the auditory ganglia. The plane of the lateral semicircular canal was approximately 8.0°-14.6° with respect to the cranial caudal (z-)axis, indicating that the orientation of the inner ear changes during growth to adulthood. |
著作権等: | This is the accepted version of the following article: [Toyoda, S., Shiraki, N., Yamada, S., Uwabe, C., Imai, H., Matsuda, T., Yoneyama, A., Takeda, T. and Takakuwa, T. (2015), Morphogenesis of the Inner Ear at Different Stages of Normal Human Development. Anat Rec, 298: 2081–2090. doi: 10.1002/ar.23268], which has been published in final form at http://dx.doi.org/10.1002/ar.23268. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. The full-text file will be made open to the public on 17 November 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/216673 |
DOI(出版社版): | 10.1002/ar.23268 |
PubMed ID: | 26369281 |
出現コレクション: | 学術雑誌掲載論文等 |
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