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タイトル: | The Digestive Tract and Derived Primordia Differentiate by Following a Precise Timeline in Human Embryos Between Carnegie Stages 11 and 13 |
著者: | Ueno, Saki Yamada, Shigehito https://orcid.org/0000-0002-8194-6927 (unconfirmed) Uwabe, Chigako Männer, Jörg Shiraki, Naoto Takakuwa, Tetsuya https://orcid.org/0000-0002-9660-9384 (unconfirmed) |
著者名の別形: | 山田, 重人 高桑, 徹也 |
キーワード: | timeline digestive tract derived primordial human embryo development |
発行日: | Apr-2016 |
出版者: | Blackwell Publishing Inc. |
誌名: | The Anatomical Record |
巻: | 299 |
号: | 4 |
開始ページ: | 439 |
終了ページ: | 449 |
抄録: | The precise mechanisms through which the digestive tract develops during the somite stage remain undefined. In this study, we examined the morphology and precise timeline of differentiation of digestive tract-derived primordia in human somite-stage embryos. We selected 37 human embryos at Carnegie Stage (CS) 11-CS13 (28-33 days after fertilization) and three-dimensionally analyzed the morphology and positioning of the digestive tract and derived primordia in all samples, using images reconstructed from histological serial sections. The digestive tract was initially formed by a narrowing of the yolk sac, and then several derived primordia such as the pharynx, lung, stomach, liver, and dorsal pancreas primordia differentiated during CS12 (21-29 somites) and CS13 (≥ 30 somites). The differentiation of four pairs of pharyngeal pouches was complete in all CS13 embryos. The respiratory primordium was recognized in≥26-somite embryos and it flattened and then branched at CS13. The trachea formed and then elongated in≥35-somite embryos. The stomach adopted a spindle shape in all≥34-somite embryos, and the liver bud was recognized in≥27-somite embryos. The dorsal pancreas appeared as definitive buddings in all but three CS13 embryos, and around these buddings, the small intestine bent in≥33-somite embryos. In≥35-somite embryos, the small intestine rotated around the cranial-caudal axis and had begun to form a primitive intestinal loop, which led to umbilical herniation. These data indicate that the digestive tract and derived primordia differentiate by following a precise timeline and exhibit limited individual variations. |
著作権等: | This is the accepted version of the following article: [Ueno, S., Yamada, S., Uwabe, C., Männer, J., Shiraki, N. and Takakuwa, T. (2016), The Digestive Tract and Derived Primordia Differentiate by Following a Precise Timeline in Human Embryos Between Carnegie Stages 11 and 13. Anat Rec, 299: 439–449. doi: 10.1002/ar.23314], which has been published in final form at http://dx.doi.org/10.1002/ar.23314 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. The full-text file will be made open to the public on 14 March 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/216677 |
DOI(出版社版): | 10.1002/ar.23314 |
PubMed ID: | 26995337 |
出現コレクション: | 学術雑誌掲載論文等 |
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