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Title: A Novel Strategy to Reveal the Latent Abnormalities in Human Embryonic Stages from a Large Embryo Collection
Authors: Kanahashi, Tohoru
Yamada, Shigehito  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8194-6927 (unconfirmed)
Tanaka, Mire
Hirose, Ayumi
Uwabe, Chigako
Kose, Katsumi
Yoneyama, Akio
Takeda, Tohoru
Takakuwa, Tetsuya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9660-9384 (unconfirmed)
Author's alias: 山田, 重人
高桑, 徹也
Keywords: magnetic resonance imaging
phase-contrast radiographic computed tomography
human development
spontaneous abortion
Issue Date: Jan-2016
Publisher: Blackwell Publishing Inc.
Journal title: The Anatomical Record
Volume: 299
Issue: 1
Start page: 8
End page: 24
Abstract: The cause of spontaneous abortion of normal conceptuses remains unknown in most cases. The study was aimed to reveal the latent abnormalities by using a large collection of embryo images from a magnetic resonance imaging (MRI) database and novel phase-contrast radiographic computed tomography (PXCT). MRI from 1, 156 embryos between Carnegie stage (CS) 14 and CS23 from the Kyoto Collection were screened by using the volume of the liver as the target organ. Embryos with liver volumes ≥2 SD above or below the mean for the stage of development were screened and examined precisely on MRI. Embryos with potentially abnormal livers were further analyzed by using PXCT. Liver abnormality was detected in all 7 embryos in the extra-small liver group and in 2 of 8 embryos in the extra-large liver group. The abnormalities in the extra-small liver group consisted of hepatic agenesis (2 embryos), hepatic hypogenesis (4), and liver lobe defect (1). Among the 7 extra-small liver group, 2 had only liver abnormalities and 5 exhibited complications in other organs. Of the 2 embryos in the extra-large liver group, one had only a single liver abnormality and the other had a morphologically abnormal liver with complications in other organs. Most of such liver abnormality cases are not survive, as liver function becomes essential. The prevalence of liver malformations in CS18 and CS21 in the intrauterine population of externally normal embryos is approximately 1.7%. The present study is the first step toward the elucidation of the latent abnormalities resulting in spontaneous abortion in externally normal embryos.
Rights: This is the accepted version of the following article: [Kanahashi, T., Yamada, S., Tanaka, M., Hirose, A., Uwabe, C., Kose, K., Yoneyama, A., Takeda, T. and Takakuwa, T. (2016), A Novel Strategy to Reveal the Latent Abnormalities in Human Embryonic Stages from a Large Embryo Collection. Anat Rec, 299: 8–24. doi: 10.1002/ar.23281], which has been published in final form at http://dx.doi.org/10.1111/cga.12140. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
The full-text file will be made open to the public on 11 December 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/216680
DOI(Published Version): 10.1002/ar.23281
PubMed ID: 26474800
Appears in Collections:Journal Articles

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