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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.bbrep.2015.08.019.pdf | 789.29 kB | Adobe PDF | 見る/開く |
| タイトル: | Solution Structure of Variant H2A.Z.1 Nucleosome Investigated by Small-Angle X-ray and Neutron Scatterings |
| 著者: | Sugiyama, Masaaki Horikoshi, Naoki Suzuki, Yuya Taguchi, Hiroyuki Kujirai, Tomoya Inoue, Rintaro   Oba, Yojiro Sato, Nobuhiro  https://orcid.org/0000-0002-6960-6567 (unconfirmed)Martel, Anne Porcar, Lionel Kurumizaka, Hitoshi |
| 著者名の別形: | 杉山, 正明 大場, 洋次郎 |
| キーワード: | Nucleosome H2A.Z.1 Small-angle X-ray scattering Small-angle neutron scattering Contrast variation Stuhrmann plot |
| 発行日: | Dec-2015 |
| 出版者: | Elsevier BV |
| 誌名: | Biochemistry and Biophysics Reports |
| 巻: | 4 |
| 開始ページ: | 28 |
| 終了ページ: | 32 |
| 抄録: | Solution structures of nucleosomes containing a human histone variant, H2A.Z.1, were measured by small-angle X-ray and neutron scatterings (SAXS and SANS). SAXS revealed that the outer shape, reflecting the DNA shape, of the H2A.Z.1 nucleosome is almost the same as that of the canonical H2A nucleosome. In contrast, SANS employing a contrast variation technique revealed that the histone octamer of the H2A.Z.1 nucleosome is smaller than that of the canonical nucleosome. The DNA within the H2A.Z.1 nucleosome was more susceptible to micrococcal nuclease than that within the canonical nucleosome. These results suggested that the DNA is loosely wrapped around the histone core in the H2A.Z.1 nucleosome. |
| 著作権等: | © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| URI: | http://hdl.handle.net/2433/217459 |
| DOI(出版社版): | 10.1016/j.bbrep.2015.08.019 |
| PubMed ID: | 29124184 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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