ダウンロード数: 254
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
ncomms13605.pdf | 1.2 MB | Adobe PDF | 見る/開く |
タイトル: | PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. |
著者: | Nagai, Yuji Kikuchi, Erika Lerchner, Walter Inoue, Ken-Ichi Ji, Bin Eldridge, Mark A G Kaneko, Hiroyuki Kimura, Yasuyuki Oh-Nishi, Arata Hori, Yukiko Kato, Yoko Hirabayashi, Toshiyuki Fujimoto, Atsushi Kumata, Katsushi Zhang, Ming-Rong Aoki, Ichio Suhara, Tetsuya Higuchi, Makoto Takada, Masahiko https://orcid.org/0000-0003-0774-2333 (unconfirmed) Richmond, Barry J Minamimoto, Takafumi |
著者名の別形: | 井上, 謙一 高田, 昌彦 |
発行日: | 6-Dec-2016 |
出版者: | Springer Nature |
誌名: | Nature communications |
巻: | 7 |
論文番号: | 13605 |
抄録: | The rostromedial caudate (rmCD) of primates is thought to contribute to reward value processing, but a causal relationship has not been established. Here we use an inhibitory DREADD (Designer Receptor Exclusively Activated by Designer Drug) to repeatedly and non-invasively inactivate rmCD of macaque monkeys. We inject an adeno-associated viral vector expressing the inhibitory DREADD, hM4Di, into the rmCD bilaterally. To visualize DREADD expression in vivo, we develop a non-invasive imaging method using positron emission tomography (PET). PET imaging provides information critical for successful chemogenetic silencing during experiments, in this case the location and level of hM4Di expression, and the relationship between agonist dose and hM4Di receptor occupancy. Here we demonstrate that inactivating bilateral rmCD through activation of hM4Di produces a significant and reproducible loss of sensitivity to reward value in monkeys. Thus, the rmCD is involved in making normal judgments about the value of reward. |
記述: | 脳内に「やる気」のスイッチ、目で見て操作 : 霊長類の生体脳で人工受容体を画像化する技術を確立、高次脳機能研究の飛躍的な進展に期待. 京都大学プレスリリース. 2016-12-16. |
著作権等: | © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/217627 |
DOI(出版社版): | 10.1038/ncomms13605 |
PubMed ID: | 27922009 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2016-12-16 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。