ダウンロード数: 273
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
cssc.201601235.pdf | 865.12 kB | Adobe PDF | 見る/開く |
タイトル: | Enzymatic Specific Production and Chemical Functionalization of Phenylpropanone Platform Monomers from Lignin. |
著者: | Ohta, Yukari Hasegawa, Ryoichi Kurosawa, Kanako Maeda, Allyn. H Koizumi, Toshio Nishimura, Hiroshi https://orcid.org/0000-0003-3807-2600 (unconfirmed) Okada, Hitomi Qu, Chen Saito, Kaori Watanabe, Takashi Hatada, Yuji |
著者名の別形: | 大田, ゆかり 小泉, 俊雄 渡辺, 隆司 秦田, 勇二 |
キーワード: | biomass enzymes lignin molecular recognition reaction mechanisms |
発行日: | 16-Dec-2016 |
出版者: | Wiley-VCH Verlag GmbH & Co. |
誌名: | ChemSusChem |
巻: | 10 |
号: | 2 |
開始ページ: | 425 |
終了ページ: | 433 |
抄録: | Enzymatic catalysis is an ecofriendly strategy for the production of high-value low-molecular-weight aromatic compounds from lignin. Although well-definable aromatic monomers have been obtained from synthetic lignin-model dimers, enzymatic-selective synthesis of platform monomers from natural lignin has not been accomplished. In this study, we successfully achieved highly specific synthesis of aromatic monomers with a phenylpropane structure directly from natural lignin using a cascade reaction of β-O-4-cleaving bacterial enzymes in one pot. Guaiacylhydroxylpropanone (GHP) and the GHP/syringylhydroxylpropanone (SHP) mixture are exclusive monomers from lignin isolated from softwood (Cryptomeria japonica) and hardwood (Eucalyptus globulus). The intermediate products in the enzymatic reactions show the capacity to accommodate highly heterologous substrates at the substrate-binding sites of the enzymes. To demonstrate the applicability of GHP as a platform chemical for bio-based industries, we chemically generate value-added GHP derivatives for bio-based polymers. Together with these chemical conversions for the valorization of lignin-derived phenylpropanone monomers, the specific and enzymatic production of the monomers directly from natural lignin is expected to provide a new stream in "white biotechnology" for sustainable biorefineries. |
記述: | 海洋性細菌の酵素で木材成分のリグニンから機能性化学品を創る : ホワイトバイオテクノロジーの新展開. 京都大学プレスリリース. 2016-12-22. |
著作権等: | © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
URI: | http://hdl.handle.net/2433/217686 |
DOI(出版社版): | 10.1002/cssc.201601235 |
PubMed ID: | 27878983 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2016-12-22-0 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。