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Title: Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans.
Authors: Kishimoto, Saya
Uno, Masaharu
Okabe, Emiko
Nono, Masanori
Nishida, Eisuke  kyouindb  KAKEN_id
Author's alias: 岸本, 沙耶
宇野, 雅晴
岡部, 恵美子
農野, 将功
西田, 栄介
Issue Date: 9-Jan-2017
Publisher: Springer Nature
Journal title: Nature communications
Volume: 8
Thesis number: 14031
Abstract: Hormesis is a biological phenomenon, whereby exposure to low levels of toxic agents or conditions increases organismal viability. It thus represents a beneficial aspect of adaptive responses to harmful environmental stimuli. Here we show that hormesis effects induced in the parental generation can be passed on to the descendants in Caenorhabditis elegans. Animals subjected to various stressors during developmental stages exhibit increased resistance to oxidative stress and proteotoxicity. The increased resistance is transmitted to the subsequent generations grown under unstressed conditions through epigenetic alterations. Our analysis reveal that the insulin/insulin-like growth factor (IGF) signalling effector DAF-16/FOXO and the heat-shock factor HSF-1 in the parental somatic cells mediate the formation of epigenetic memory, which is maintained through the histone H3 lysine 4 trimethylase complex in the germline across generations. The elicitation of memory requires the transcription factor SKN-1/Nrf in somatic tissues. We propose that germ-to-soma communication across generations is an essential framework for the transgenerational inheritance of acquired traits, which provides the offspring with survival advantages to deal with environmental perturbation.
Description: 獲得形質は遺伝する? : 親世代で受けた環境ストレスが子孫の生存力を高める. 京都大学プレスリリース. 2017-01-11.
Rights: © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
DOI(Published Version): 10.1038/ncomms14031
PubMed ID: 28067237
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