ダウンロード数: 223
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
journal.pone.0167141.pdf | 974.86 kB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Kitagori, Koji | en |
dc.contributor.author | Yoshifuji, Hajime | en |
dc.contributor.author | Oku, Takuma | en |
dc.contributor.author | Sasaki, Chiyomi | en |
dc.contributor.author | Miyata, Hitomi | en |
dc.contributor.author | Mori, Keita P. | en |
dc.contributor.author | Nakajima, Toshiki | en |
dc.contributor.author | Ohmura, Koichiro | en |
dc.contributor.author | Kawabata, Daisuke | en |
dc.contributor.author | Yukawa, Naoichiro | en |
dc.contributor.author | Imura, Yoshitaka | en |
dc.contributor.author | Murakami, Kosaku | en |
dc.contributor.author | Nakashima, Ran | en |
dc.contributor.author | Usui, Takashi | en |
dc.contributor.author | Fujii, Takao | en |
dc.contributor.author | Sakai, Kaoru | en |
dc.contributor.author | Yanagita, Motoko | en |
dc.contributor.author | Hirayama, Yoshitaka | en |
dc.contributor.author | Mimori, Tsuneyo | en |
dc.contributor.alternative | 吉藤, 元 | ja |
dc.contributor.alternative | 宮田, 仁美 | ja |
dc.contributor.alternative | 大村, 浩一郎 | ja |
dc.contributor.alternative | 湯川, 尚一郎 | ja |
dc.contributor.alternative | 井村, 嘉孝 | ja |
dc.contributor.alternative | 藤井, 隆夫 | ja |
dc.contributor.alternative | 柳田, 素子 | ja |
dc.contributor.alternative | 三森, 経世 | ja |
dc.date.accessioned | 2017-01-17T04:51:38Z | - |
dc.date.available | 2017-01-17T04:51:38Z | - |
dc.date.issued | 2016-12-19 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2433/217828 | - |
dc.description.abstract | We assessed the utility of two forms of osteopontin (OPN), OPN full and its cleaved form (OPN N-half), in plasma and urine as markers of disease activity in lupus nephritis (LN). Samples were collected from patients with systemic lupus erythematosus (SLE) (LN: N = 29, non- LN: N = 27), IgA nephropathy (IgAN) (N = 14), minimal change nephrotic syndrome (MCNS) (N = 5), diabetic nephropathy (DN) (N = 14) and healthy volunteers (HC) (N = 17). While there was no significant difference in urine OPN full concentration between groups, urine OPN N-half concentration was significantly higher in patients with LN than HC (p < 0.05). Moreover, urine OPN N-half was higher in LN patients with overt proteinuria (urine protein/ creatinine ratio: P/C > 0.5) than LN patients with minimal proteinuria (P/C < 0.5, p < 0.0001), and also higher than in DN patients with overt proteinuria (P/C > 0.5, p < 0.01). Urine thrombin activity correlated with urine OPN N-half concentration (p < 0.0001), but not with urine OPN full concentration. These results suggest that urine OPN N-half concentration reflects renal inflammation. Thus, urine OPN N-half may be a novel disease activity marker for LN. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science | en |
dc.rights | © 2016 Kitagori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.title | Cleaved form of osteopontin in urine as a clinical marker of lupus nephritis | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | PLOS ONE | en |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 12 | - |
dc.relation.doi | 10.1371/journal.pone.0167141 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e0167141 | - |
dc.identifier.pmid | 27992535 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。