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タイトル: Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein.
著者: Hashimoto, Takuma
Horikawa, Daiki D.
Saito, Yuki
Kuwahara, Hirokazu
Kozuka-Hata, Hiroko
Shin-I, Tadasu
Minakuchi, Yohei
Ohishi, Kazuko
Motoyama, Ayuko
Aizu, Tomoyuki
Enomoto, Atsushi
Kondo, Koyuki
Tanaka, Sae
Hara, Yuichiro
Koshikawa, Shigeyuki  kyouindb  KAKEN_id
Sagara, Hiroshi
Miura, Toru
Yokobori, Shin-ichi
Miyagawa, Kiyoshi
Suzuki, Yutaka
Kubo, Takeo
Oyama, Masaaki
Kohara, Yuji
Fujiyama, Asao
Arakawa, Kazuharu
Katayama, Toshiaki
Toyoda, Atsushi
Kunieda, Takekazu
著者名の別形: 越川, 滋行
発行日: 20-Sep-2016
出版者: Springer Nature
誌名: Nature communications
巻: 7
論文番号: 12808
抄録: Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade species tolerate almost complete dehydration and exhibit extraordinary tolerance to various physical extremes in the dehydrated state. Here we determine a high-quality genome sequence of Ramazzottius varieornatus, one of the most stress-tolerant tardigrade species. Precise gene repertoire analyses reveal the presence of a small proportion (1.2% or less) of putative foreign genes, loss of gene pathways that promote stress damage, expansion of gene families related to ameliorating damage, and evolution and high expression of novel tardigrade-unique proteins. Minor changes in the gene expression profiles during dehydration and rehydration suggest constitutive expression of tolerance-related genes. Using human cultured cells, we demonstrate that a tardigrade-unique DNA-associating protein suppresses X-ray-induced DNA damage by -40% and improves radiotolerance. These findings indicate the relevance of tardigrade-unique proteins to tolerability and tardigrades could be a bountiful source of new protection genes and mechanisms.
著作権等: © The Author(s) 2016 This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
URI: http://hdl.handle.net/2433/218035
DOI(出版社版): 10.1038/ncomms12808
PubMed ID: 27649274
出現コレクション:学術雑誌掲載論文等

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