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dc.contributor.author | Yokoyama, Marie | en |
dc.contributor.author | Matsuo, Naoki | en |
dc.contributor.alternative | 横山, まりえ | ja |
dc.contributor.alternative | 松尾, 直毅 | ja |
dc.date.accessioned | 2017-02-23T07:19:43Z | - |
dc.date.available | 2017-02-23T07:19:43Z | - |
dc.date.issued | 2016-11-07 | - |
dc.identifier.issn | 1662-5153 | - |
dc.identifier.uri | http://hdl.handle.net/2433/218384 | - |
dc.description.abstract | The details of contextual or episodic memories are lost and generalized with the passage of time. Proper generalization may underlie the formation and assimilation of semantic memories and enable animals to adapt to ever-changing environments, whereas overgeneralization of fear memory evokes maladaptive fear responses to harmless stimuli, which is a symptom of anxiety disorders such as post-traumatic stress disorder (PTSD). To understand the neural basis of fear memory generalization, we investigated the patterns of neuronal ensemble reactivation during memory retrieval when contextual fear memory expression is generalized using transgenic mice that allowed us to visualize specific neuronal ensembles activated during memory encoding and retrieval. We found preferential reactivations of neuronal ensembles in the primary somatosensory cortex (SS), when mice were returned to the conditioned context to retrieve their memory 1 day after conditioning. In the hippocampal dentate gyrus (DG), exclusively separated ensemble reactivation was observed when mice were exposed to a novel context. These results suggest that the DG as well as the SS were likely to distinguish the two different contexts at the ensemble activity level when memory is not generalized at the behavioral level. However, 9 days after conditioning when animals exhibited generalized fear, the unique reactivation pattern in the DG, but not in the SS, was lost. Our results suggest that the alternations in the ensemble representation within the DG, or in upstream structures that link the sensory cortex to the hippocampus, may underlie generalized contextual fear memory expression. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media SA | en |
dc.rights | © 2016 Yokoyama and Matsuo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en |
dc.subject | Context | en |
dc.subject | Hippocampus | en |
dc.subject | Memory engram | en |
dc.subject | Mice | en |
dc.subject | PTSD | en |
dc.title | Loss of Ensemble Segregation in Dentate Gyrus, but not in Somatosensory Cortex, during Contextual Fear Memory Generalization | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Frontiers in Behavioral Neuroscience | en |
dc.identifier.volume | 10 | - |
dc.relation.doi | 10.3389/fnbeh.2016.00218 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 218 | - |
dc.address | Career-Path Promotion Unit for Young Life Scientists, Kyoto University | en |
dc.address | The Hakubi Center for Advanced Research, Kyoto University | en |
dc.address.alternative | 京都大・生命科学系キャリアパス形成ユニット | ja |
dc.address.alternative | 京都大・白眉センター | ja |
dc.identifier.pmid | 27872586 | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 1662-5153 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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