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dc.contributor.author | Saito, Yuichiro | en |
dc.contributor.author | Komatsu, Kenshi | en |
dc.contributor.alternative | 小松, 賢志 | ja |
dc.date.accessioned | 2017-02-24T07:38:43Z | - |
dc.date.available | 2017-02-24T07:38:43Z | - |
dc.date.issued | 2015-08-20 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | http://hdl.handle.net/2433/218415 | - |
dc.description.abstract | Nijmegen breakage syndrome (NBS) is a recessive genetic disorder characterized by increased sensitivity to ionizing radiation (IR) and a high frequency of malignancies. NBS1, a product of the mutated gene in NBS, contains several protein interaction domains in the N-terminus and C-terminus. The C-terminus of NBS1 is essential for interactions with MRE11, a homologous recombination repair nuclease, and ATM, a key player in signal transduction after the generation of DNA double-strand breaks (DSBs), which is induced by IR. Moreover, NBS1 regulates chromatin remodeling during DSB repair by histone H2B ubiquitination through binding to RNF20 at the C-terminus. Thus, NBS1 is considered as the first protein to be recruited to DSB sites, wherein it acts as a sensor or mediator of DSB damage responses. In addition to DSB response, we showed that NBS1 initiates Polη-dependent translesion DNA synthesis by recruiting RAD18 through its binding at the NBS1 C-terminus after UV exposure, and it also functions after the generation of interstrand crosslink DNA damage. Thus, NBS1 has multifunctional roles in response to DNA damage from a variety of genotoxic agents, including IR. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | en |
dc.rights | © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.subject | Chromatin remodeling | en |
dc.subject | DNA repair | en |
dc.subject | Homologous recombination | en |
dc.subject | NBS1 | en |
dc.subject | Translesion DNA synthesis | en |
dc.title | Functional role of NBS1 in radiation damage response and translesion DNA synthesis | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Biomolecules | en |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 1990 | - |
dc.identifier.epage | 2002 | - |
dc.relation.doi | 10.3390/biom5031990 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 26308066 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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