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j.jphs.2015.06.007.pdf | 1.05 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Okuma, Chihiro | en |
dc.contributor.author | Ohta, Takeshi | en |
dc.contributor.author | Tadaki, Hironobu | en |
dc.contributor.author | Ishigure, Tatsuya | en |
dc.contributor.author | Sakata, Shohei | en |
dc.contributor.author | Taniuchi, Hideyuki | en |
dc.contributor.author | Sano, Ryuhei | en |
dc.contributor.author | Hamada, Hiromi | en |
dc.contributor.author | Kume, Shinichi | en |
dc.contributor.author | Nishiu, Jun | en |
dc.contributor.author | Kakutani, Makoto | en |
dc.contributor.alternative | 久米, 新一 | ja |
dc.date.accessioned | 2017-02-28T04:06:31Z | - |
dc.date.available | 2017-02-28T04:06:31Z | - |
dc.date.issued | 2015-04-09 | - |
dc.identifier.issn | 1347-8648 | - |
dc.identifier.uri | http://hdl.handle.net/2433/218471 | - |
dc.description.abstract | Aim Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic MGAT activity and hepatic lipid metabolism. Results JTP-103237 reduced hepatic triglyceride content and hepatic MGAT activity in a high sucrose very low fat (HSVLF) diet induced fatty liver model. Interestingly, JTP-103237 suppressed not only triglyceride (TG) and diacylglycerol (DG) synthesis, but also fatty acid (FA) synthesis (de novo lipogenesis) in this model. JTP-103237 also suppressed lipogenesis-related gene expression, such as sterol regulatory element-binding protein 1-c. Moreover, JTP-103237 decreased plasma glucose levels and total cholesterol and reduced the accumulation of epididymal fats in HSVLF diet fed mice. Conclusion In the present study, JTP-103237 prevented carbohydrate-induced fatty liver and suppressed both TG synthesis and de novo lipogenesis, suggesting MGAT inhibitor may prevent carbohydrate-induced metabolic disorders, including NAFLD, obesity and diabetes. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Japanese Pharmacological Society | en |
dc.rights | © 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ icenses/by-nc-nd/4.0/). | en |
dc.subject | de novo lipogenesis | en |
dc.subject | JTP-103237 | en |
dc.subject | Monoacyglycerol acyltransferase | en |
dc.subject | Nonalcoholic fatty liver disease | en |
dc.title | JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Journal of Pharmacological Sciences | en |
dc.identifier.volume | 128 | - |
dc.identifier.spage | 150 | - |
dc.identifier.epage | 157 | - |
dc.relation.doi | 10.1016/j.jphs.2015.06.007 | - |
dc.textversion | publisher | - |
dc.address | Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University | en |
dc.identifier.pmid | 26215699 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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