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dc.contributor.author | Kimura, Hiroyuki | en |
dc.contributor.author | Tomatsu, Kenji | en |
dc.contributor.author | Saiki, Hidekazu | en |
dc.contributor.author | Arimitsu, Kenji | en |
dc.contributor.author | Ono, Masahiro | en |
dc.contributor.author | Kawashima, Hidekazu | en |
dc.contributor.author | Iwata, Ren | en |
dc.contributor.author | Nakanishi, Hiroaki | en |
dc.contributor.author | Ozeki, Eiichi | en |
dc.contributor.author | Kuge, Yuji | en |
dc.contributor.author | Saji, Hideo | en |
dc.contributor.alternative | 佐治, 英郎 | ja |
dc.date.accessioned | 2017-03-08T05:27:19Z | - |
dc.date.available | 2017-03-08T05:27:19Z | - |
dc.date.issued | 2016-07-13 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2433/218702 | - |
dc.description.abstract | In the field of positron emission tomography (PET) radiochemistry, compact microreactors provide reliable and reproducible synthesis methods that reduce the use of expensive precursors for radiolabeling and make effective use of the limited space in a hot cell. To develop more compact microreactors for radiosynthesis of 18F-labeled compounds required for the multistep procedure, we attempted radiosynthesis of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) via a three-step procedure using a microreactor. We examined individual steps for [18F]SFB using a batch reactor and microreactor and developed a new continuous-flow synthetic method with a single microfluidic chip to achieve rapid and efficient radiosynthesis of [18F]SFB. In the synthesis of [18F]SFB using this continuous-flow method, the three-step reaction was successfully completed within 6.5 min and the radiochemical yield was 64 ± 2% (n = 5). In addition, it was shown that the quality of [18F]SFB synthesized on this method was equal to that synthesized by conventional methods using a batch reactor in the radiolabeling of bovine serum albumin with [18F]SFB. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science | en |
dc.rights | © 2016 Kimura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.title | Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | PLOS ONE | en |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 7 | - |
dc.relation.doi | 10.1371/journal.pone.0159303 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e0159303 | - |
dc.identifier.pmid | 27410684 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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