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|---|---|---|---|---|
| srep33988.pdf | 1.87 MB | Adobe PDF | 見る/開く |
| タイトル: | A naturally occurring bovine APOBEC3 confers resistance to bovine lentiviruses: implication for the co-evolution of bovids and their lentiviruses |
| 著者: | Yamada, Eri Yoshikawa, Rokusuke Nakano, Yusuke Misawa, Naoko Kobayashi, Tomoko Ren, Fengrong Izumi, Taisuke Miyazawa, Takayuki  Koyanagi, Yoshio   https://orcid.org/0000-0002-3007-6642 (unconfirmed)Sato, Kei |
| 著者名の別形: | 山田, 英里 吉川, 禄助 中野, 雄介 三沢, 尚子 小林, 朋子 任, 鳳蓉 泉, 泰 輔 宮沢, 孝幸 小柳, 義夫 佐藤, 圭 |
| 発行日: | Dec-2016 |
| 出版者: | Springer Nature |
| 誌名: | Scientific Reports |
| 巻: | 6 |
| 論文番号: | 33988 |
| 抄録: | Mammals have co-evolved with lentiviruses for a long time. As evidence, viral infectivity factor (Vif), encoded by lentiviruses, antagonizes the anti-viral action of cellular APOBEC3 of their hosts. Here, we address the co-evolutionary dynamics of bovine APOBEC3 and the following two bovine lentiviruses: bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV). We determined the sequences of three APOBEC3 genes of bovids belonging to the genera Bos and Bison and showed that bovine APOBEC3Z3 is under a strong positive selection. We found that APOBEC3Z3 of gaur, a bovid in the genus Bos, acquired resistance to JDV Vif-mediated degradation after diverging from the other bovids through conversion of the structural composition of the loop 1 domain. Interestingly, the resistance of gaur APOBEC3Z3 can be attributed to the positive selection of residue 62. This study provides the first evidence, suggesting that a co-evolutionary arms race between bovids and lentiviruses occurred in Asia. |
| 著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| URI: | http://hdl.handle.net/2433/218824 |
| DOI(出版社版): | 10.1038/srep33988 |
| PubMed ID: | 27665724 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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