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Title: Global Escherichia coli sequence type 131 clade with blaCTX-M-27 gene
Authors: Matsumura, Yasufumi  kyouindb  KAKEN_id  orcid (unconfirmed)
Pitout, Johann D D
Gomi, Ryota  kyouindb  KAKEN_id
Matsuda, Tomonari  kyouindb  KAKEN_id
Noguchi, Taro  kyouindb  KAKEN_id  orcid (unconfirmed)
Yamamoto, Masaki
Peirano, Gisele
De Vinney, Rebekah
Bradford, Patricia A.
Motyl, Mary R.
Tanaka, Michio
Nagao, Miki  kyouindb  KAKEN_id  orcid (unconfirmed)
Takakura, Shunji
Ichiyama, Satoshi  kyouindb  KAKEN_id
Author's alias: 松村, 康史
山本, 正樹
長尾, 美紀
髙倉, 俊二
一山, 智
Issue Date: Nov-2016
Publisher: Centers for Disease Control and Prevention (CDC)
Journal title: Emerging Infectious Diseases
Volume: 22
Issue: 11
Start page: 1900
End page: 1907
Abstract: The Escherichia coli sequence type (ST) 131 C2/H30Rx clade with the blaCTX-M-15 gene had been most responsible for the global dissemination of extended-spectrum β-lactamase (ESBL)-producing E. coli. ST131 C1/H30R with blaCTX-M-27 emerged among ESBL-producing E. coli in Japan during the late 2000s. To investigate the possible expansion of a single clade, we performed whole-genome sequencing for 43 Japan and 10 global ST131 isolates with blaCTX-M-27 (n = 16), blaCTX-M-14 (n = 16), blaCTX-M-15 (n = 13), and others (n = 8). We also included 8 ST131 genomes available in public databases. Core genome-based analysis of 61 isolates showed that ST131 with blaCTX-M-27 from 5 countries formed a distinct cluster within the C1/H30R clade, named C1-M27 clade. Accessory genome analysis identified a unique prophage-like region, supporting C1-M27 as a distinct clade. Our findings indicate that the increase of ESBL-producing E. coli in Japan is due mainly to emergence of the C1-M27 clade.
Rights: All content is freely available without charge to the user or his/her institution. In accordance with the Budapest Open Access Initiative definition of Open Access, users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. Because the journal is in the public domain, its usage policy also conforms to conditions set for by Creative Commons.
DOI(Published Version): 10.3201/eid2211.160519
PubMed ID: 27767006
Appears in Collections:Journal Articles

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