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eid2211.160519.pdf | 5.96 MB | Adobe PDF | 見る/開く |
タイトル: | Global Escherichia coli sequence type 131 clade with blaCTX-M-27 gene |
著者: | Matsumura, Yasufumi https://orcid.org/0000-0001-8595-8944 (unconfirmed) Pitout, Johann D D Gomi, Ryota https://orcid.org/0000-0002-3299-333X (unconfirmed) Matsuda, Tomonari https://orcid.org/0000-0002-6177-1066 (unconfirmed) Noguchi, Taro https://orcid.org/0000-0002-6601-6799 (unconfirmed) Yamamoto, Masaki Peirano, Gisele De Vinney, Rebekah Bradford, Patricia A. Motyl, Mary R. Tanaka, Michio Nagao, Miki https://orcid.org/0000-0002-8886-6145 (unconfirmed) Takakura, Shunji Ichiyama, Satoshi |
著者名の別形: | 松村, 康史 山本, 正樹 長尾, 美紀 髙倉, 俊二 一山, 智 |
発行日: | Nov-2016 |
出版者: | Centers for Disease Control and Prevention (CDC) |
誌名: | Emerging Infectious Diseases |
巻: | 22 |
号: | 11 |
開始ページ: | 1900 |
終了ページ: | 1907 |
抄録: | The Escherichia coli sequence type (ST) 131 C2/H30Rx clade with the blaCTX-M-15 gene had been most responsible for the global dissemination of extended-spectrum β-lactamase (ESBL)-producing E. coli. ST131 C1/H30R with blaCTX-M-27 emerged among ESBL-producing E. coli in Japan during the late 2000s. To investigate the possible expansion of a single clade, we performed whole-genome sequencing for 43 Japan and 10 global ST131 isolates with blaCTX-M-27 (n = 16), blaCTX-M-14 (n = 16), blaCTX-M-15 (n = 13), and others (n = 8). We also included 8 ST131 genomes available in public databases. Core genome-based analysis of 61 isolates showed that ST131 with blaCTX-M-27 from 5 countries formed a distinct cluster within the C1/H30R clade, named C1-M27 clade. Accessory genome analysis identified a unique prophage-like region, supporting C1-M27 as a distinct clade. Our findings indicate that the increase of ESBL-producing E. coli in Japan is due mainly to emergence of the C1-M27 clade. |
著作権等: | All content is freely available without charge to the user or his/her institution. In accordance with the Budapest Open Access Initiative definition of Open Access, users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. Because the journal is in the public domain, its usage policy also conforms to conditions set for by Creative Commons. |
URI: | http://hdl.handle.net/2433/218889 |
DOI(出版社版): | 10.3201/eid2211.160519 |
PubMed ID: | 27767006 |
出現コレクション: | 学術雑誌掲載論文等 |
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