|Title:||Global Escherichia coli sequence type 131 clade with blaCTX-M-27 gene|
|Authors:||Matsumura, Yasufumi https://orcid.org/0000-0001-8595-8944 (unconfirmed)|
Pitout, Johann D D
Noguchi, Taro https://orcid.org/0000-0002-6601-6799 (unconfirmed)
De Vinney, Rebekah
Bradford, Patricia A.
Motyl, Mary R.
Nagao, Miki https://orcid.org/0000-0002-8886-6145 (unconfirmed)
|Author's alias:||松村, 康史|
|Publisher:||Centers for Disease Control and Prevention (CDC)|
|Journal title:||Emerging Infectious Diseases|
|Abstract:||The Escherichia coli sequence type (ST) 131 C2/H30Rx clade with the blaCTX-M-15 gene had been most responsible for the global dissemination of extended-spectrum β-lactamase (ESBL)-producing E. coli. ST131 C1/H30R with blaCTX-M-27 emerged among ESBL-producing E. coli in Japan during the late 2000s. To investigate the possible expansion of a single clade, we performed whole-genome sequencing for 43 Japan and 10 global ST131 isolates with blaCTX-M-27 (n = 16), blaCTX-M-14 (n = 16), blaCTX-M-15 (n = 13), and others (n = 8). We also included 8 ST131 genomes available in public databases. Core genome-based analysis of 61 isolates showed that ST131 with blaCTX-M-27 from 5 countries formed a distinct cluster within the C1/H30R clade, named C1-M27 clade. Accessory genome analysis identified a unique prophage-like region, supporting C1-M27 as a distinct clade. Our findings indicate that the increase of ESBL-producing E. coli in Japan is due mainly to emergence of the C1-M27 clade.|
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|Appears in Collections:||Journal Articles |
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