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Title: GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior
Authors: Aizawa, Fuka
Nishinaka, Takashi
Yamashita, Takuya
Nakamoto, Kazuo
Kurihara, Takashi
Hirasawa, Akira
Kasuya, Fumiyo
Miyata, Atsuro
Tokuyama, Shogo
Author's alias: 平澤, 明
Keywords: GPR40/FFAR1
Free fatty acid
Sucrose preference
Issue Date: Dec-2016
Publisher: Elsevier B.V.
Journal title: Journal of Pharmacological Sciences
Volume: 132
Issue: 4
Start page: 249
End page: 254
Abstract: The free fatty acid receptor 1 (GPR40/FFAR1) is a G protein-coupled receptor, which is activated by long chain fatty acids. We have previously demonstrated that activation of brain GPR40/FFAR1 exerts an antinociceptive effect that is mediated by the modulation of the descending pain control system. However, it is unclear whether brain GPR40/FFAR1 contributes to emotional function. In this study, we investigated the involvement of GPR40/FFAR1 in emotional behavior using GPR40/FFAR1 deficient (knockout, KO) mice. The emotional behavior in wild and KO male mice was evaluated at 9–10 weeks of age by the elevated plus-maze test, open field test, social interaction test, and sucrose preference test. Brain monoamines levels were measured using LC–MS/MS. The elevated plus-maze test and open field tests revealed that the KO mice reduced anxiety-like behavior. There were no differences in locomotor activity or social behavior between the wild and KO mice. In the sucrose preference test, the KO mice showed reduction in sucrose preference and intake. The level of noradrenaline was higher in the hippocampus, medulla oblongata, hypothalamus and midbrain of KO mice. Therefore, these results suggest that brain GPR40/FFAR1 is associated with anxiety- and depression-related behavior regulated by the increment of noradrenaline in the brain.
Rights: © 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (
DOI(Published Version): 10.1016/j.jphs.2016.09.007
PubMed ID: 27979701
Appears in Collections:Journal Articles

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