ダウンロード数: 177
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
jvms.16-0513.pdf | 1.36 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | YAMASHITA, Masamichi | en |
dc.contributor.author | IMAGAWA, Tomohiro | en |
dc.contributor.author | SAKO, Yasuhito | en |
dc.contributor.author | OKAMOTO, Munehiro | en |
dc.contributor.author | YANAGIDA, Tetsuya | en |
dc.contributor.author | OKAMOTO, Yoshiharu | en |
dc.contributor.author | TSUKA, Takeshi | en |
dc.contributor.author | OSAKI, Tomohiro | en |
dc.contributor.author | ITO, Akira | en |
dc.date.accessioned | 2017-03-15T07:24:08Z | - |
dc.date.available | 2017-03-15T07:24:08Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0916-7250 | - |
dc.identifier.uri | http://hdl.handle.net/2433/218927 | - |
dc.description.abstract | Serology is important for the diagnosis and follow-up of human alveolar echinococcosis (AE). However, patient conditions are highly variable among those with AE, and antibody responses in serological follow-up have not been well-defined. We recently described a new AE rat model established by implantation of small AE tissue into a single arbitrary location in the liver; no metastasis and dissemination were observed. In the present study, we examined the serological characteristics in our rat model before and after surgical treatment. The results showed that antibody responses against crude antigens were increased at one month after transplantation and similar to those of other model animals. For the antigen Em18, antibody responses were slower in our rat model than in other animal models. After surgical resection, changes in antibody responses against Em18 were similar to those observed in human patients with AE. Because of the slow growth of lesions, establishment of a single hepatic lesion and patterns of antibody responses, our rat model may be useful for clarifying follow-up serodiagnoses in human AE and determining the mechanisms of multi-organ involvement by primary infection with oncospheres rather than metastasis. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Japanese Society of Veterinary Science | en |
dc.publisher.alternative | 日本獣医学会 | ja |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-ncnd) License <http://creativecommons.org/licenses/by-nc-nd/4.0/>. | en |
dc.subject | Echinococcus multilocularis | en |
dc.subject | Em18 | en |
dc.subject | rat model | en |
dc.subject | serology | en |
dc.title | Serological validation of an alveolar echinococcosis rat model with a single hepatic lesion | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Journal of Veterinary Medical Science | en |
dc.identifier.volume | 79 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 308 | - |
dc.identifier.epage | 313 | - |
dc.relation.doi | 10.1292/jvms.16-0513 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 27890868 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。