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タイトル: Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance
著者: Harada, Hiroshi
著者名の別形: 原田, 浩
キーワード: hypoxia-inducible factor 1 (HIF-1)
radioresistance
cancer
metabolic reprogramming
tumor blood vessels
cell cycle
Warburg effect
発行日: 16-Aug-2016
出版者: Oxford University Press
誌名: Journal of Radiation Research
巻: 57
号: S1
開始ページ: i99
終了ページ: i105
抄録: Tumor hypoxia has been attracting increasing attention in the fields of radiation biology and oncology since Thomlinson and Gray detected hypoxic cells in malignant solid tumors and showed that they exert a negative impact on the outcome of radiation therapy. This unfavorable influence has, at least partly, been attributed to cancer cells acquiring a radioresistant phenotype through the activation of the transcription factor, hypoxia-inducible factor 1 (HIF-1). On the other hand, accumulating evidence has recently revealed that, even though HIF-1 is recognized as an important regulator of cellular adaptive responses to hypoxia, it may not become active and induce tumor radioresistance under hypoxic conditions only. The mechanisms by which HIF-1 is activated in cancer cells not only under hypoxic conditions, but also under normoxic conditions, through cancer-specific genetic alterations and the resultant imbalance in intermediate metabolites have been summarized herein. The relevance of the HIF-1-mediated characteristic features of cancer cells, such as the production of antioxidants through reprogramming of the glucose metabolic pathway and cell cycle regulation, for tumor radioresistance has also been reviewed.
著作権等: © 2016 The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/219575
DOI(出版社版): 10.1093/jrr/rrw012
出現コレクション:学術雑誌掲載論文等

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