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タイトル: | Single-neuron and genetic correlates of autistic behavior in macaque |
著者: | Yoshida, Kyoko Go, Yasuhiro Kushima, Itaru Toyoda, Atsushi Fujiyama, Asao Imai, Hiroo Saito, Nobuhito Iriki, Atsushi Ozaki, Norio Isoda, Masaki |
著者名の別形: | 今井, 啓雄 |
キーワード: | Autism behavioral neuroscience neurons developmental neuroscience genomic analysis |
発行日: | 21-Sep-2016 |
出版者: | American Association for the Advancement of Science (AAAS) |
誌名: | Science Advances |
巻: | 2 |
号: | 9 |
論文番号: | e1600558 |
抄録: | Atypical neurodevelopment in autism spectrum disorder is a mystery, defying explanation despite increasing attention. We report on a Japanese macaque that spontaneously exhibited autistic traits, namely, impaired social ability as well as restricted and repetitive behaviors, along with our single-neuron and genomic analyses. Its social ability was measured in a turn-taking task, where two monkeys monitor each other’s actions for adaptive behavioral planning. In its brain, the medial frontal neurons responding to others’ actions, abundant in the controls, were almost nonexistent. In its genes, whole-exome sequencing and copy number variation analyses identified rare coding variants linked to human neuropsychiatric disorders in 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C) and adenosine triphosphate (ATP)–binding cassette subfamily A13 (ABCA13). This combination of systems neuroscience and cognitive genomics in macaques suggests a new, phenotype-to-genotype approach to studying mental disorders. |
著作権等: | © 2016, The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/224811 |
DOI(出版社版): | 10.1126/sciadv.1600558 |
PubMed ID: | 27679817 |
出現コレクション: | 学術雑誌掲載論文等 |
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