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dc.contributor.author | Egawa, Tatsuro | en |
dc.contributor.author | Tsuda, Satoshi | en |
dc.contributor.author | Goto, Ayumi | en |
dc.contributor.author | Ohno, Yoshitaka | en |
dc.contributor.author | Yokoyama, Shingo | en |
dc.contributor.author | Goto, Katsumasa | en |
dc.contributor.author | Hayashi, Tatsuya | en |
dc.contributor.alternative | 江川, 達郎 | ja |
dc.date.accessioned | 2017-05-29T06:27:21Z | - |
dc.date.available | 2017-05-29T06:27:21Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | http://hdl.handle.net/2433/225061 | - |
dc.description.abstract | Diets enriched with advanced glycation end products (AGE) have recently been related to muscle dysfunction processes. However, it remains unclear whether long-term exposure to an AGE-enriched diet impacts physiological characteristics of skeletal muscles. Therefore, we explored the differences in skeletal muscle mass, contractile function and molecular responses between mice receiving a diet high in AGE (H-AGE) and low in AGE (L-AGE) for 16 weeks. There were no significant differences between L-AGE and H-AGE mice with regard to body weight, food intake or epididymal fat pad weight. However, extensor digitorum longus (EDL) and plantaris (PLA) muscle weights in H-AGE mice were lower compared with L-AGE mice. Higher levels of N[ε] -(carboxymethyl)-l-lysine, a marker for AGE, in EDL muscles of H-AGE mice were observed compared with L-AGE mice. H-AGE mice showed lower muscle strength and endurance in vivo and lower muscle force production of PLA muscle in vitro. mRNA expression levels of myogenic factors including myogenic factor 5 and myogenic differentiation in EDL muscle were lower in H-AGE mice compared with L-AGE mice. The phosphorylation status of 70-kDa ribosomal protein S6 kinase Thr[389], an indicator of protein synthesis signalling, was lower in EDL muscle of H-AGE mice than that of L-AGE mice. These findings suggest that long-term exposure to an AGE-enriched diet impairs skeletal muscle growth and muscle contractile function, and that these muscle dysfunctions may be attributed to the inhibition of myogenic potential and protein synthesis. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cambridge University Press (CUP) | en |
dc.rights | © The Authors 2017 | en |
dc.rights | The full-text file will be made open to the public on 1 January 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.subject | Muscle strength | en |
dc.subject | Muscle fatigue resistance | en |
dc.subject | Muscle force production | en |
dc.subject | Myogenesis | en |
dc.subject | Protein synthesis | en |
dc.title | Potential involvement of dietary advanced glycation end products in impairment of skeletal muscle growth and muscle contractile function in mice | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00574708 | - |
dc.identifier.jtitle | British Journal of Nutrition | en |
dc.identifier.volume | 117 | - |
dc.identifier.spage | 21 | - |
dc.identifier.epage | 29 | - |
dc.relation.doi | 10.1017/S0007114516004591 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 28093090 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2018-01-01 | - |
dc.identifier.pissn | 0007-1145 | - |
dc.identifier.eissn | 1475-2662 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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