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タイトル: | Changes in clinical symptoms and functional disability in patients with coexisting patellofemoral and tibiofemoral osteoarthritis: a 1-year prospective cohort study |
著者: | Iijima, Hirotaka Fukutani, Naoto Isho, Takuya Yamamoto, Yuko Hiraoka, Masakazu Miyanobu, Kazuyuki Jinnouchi, Masashi Kaneda, Eishi Aoyama, Tomoki Kuroki, Hiroshi Matsuda, Shuichi |
著者名の別形: | 飯島, 弘貴 福谷, 直人 青山, 朋樹 黒木, 裕士 松田, 秀一 |
キーワード: | Patellofemoral osteoarthritis Tibiofemoral osteoarthritis Knee pain Disability |
発行日: | 24-Mar-2017 |
出版者: | Springer Nature |
誌名: | BMC Musculoskeletal Disorders |
巻: | 18 |
論文番号: | 126 |
抄録: | [Background]This 1-year prospective cohort study aimed to compare the changes in clinical symptoms and functional disability between patients with coexisting patellofemoral (PF) and tibiofemoral (TF) osteoarthritis (OA) and those with isolated TFOA. [Methods]Seventy-two patients with medial knee OA were enrolled. Knee pain and functional disability were assessed at baseline and at 1-year follow-up using the Japanese Knee Osteoarthritis Measure (JKOM) and a visual analog scale (VAS). We performed two-way analysis of covariance for the clinical outcome variables to examine, time (baseline and follow-up), group (coexisting PFOA and isolated TFOA), and time-group interaction effects. Furthermore, we conducted post-hoc exploratory analysis to address the possibility that dividing patients according to location of PFOA (i.e., isolated lateral, isolated medial, and mixed [bilateral]) may identify a distinct subgroup with different changes in clinical outcomes at 1-year follow-up. [Results]We detected group effects only in scores of the JKOM pain subscale (P = 0.012) and VAS (P = 0.033), adjusted for age, sex, and body mass index. Patients with coexisting PFOA have stable moderate level knee pain and functional disability throughout the year which is significantly worse than that in those with isolated TFOA. Post-hoc subgroup analysis demonstrated that change of knee pain likely varied with location of PFOA. Patients with isolated lateral PFOA had mild/moderate level knee pain, and their VAS scores were likely to improve, whereas those with mixed PFOA exhibited stable to worsening moderate/severe knee pain. [Conclusions]Although we did not detect differences in changes in clinical symptoms and functional disability between patients with coexisting PFOA and those with isolated TFOA, our findings indicate that patients with coexisting PFOA had worse clinical symptoms and functional disability than those with isolated TFOA. The results of the exploratory analysis suggested that patients with coexisting PFOA might have heterogeneous clinical outcomes, and presence of mixed PFOA might be an indicator of severe clinical knee OA. |
著作権等: | © The Author(s). 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
URI: | http://hdl.handle.net/2433/226185 |
DOI(出版社版): | 10.1186/s12891-017-1486-4 |
PubMed ID: | 28340623 |
出現コレクション: | 学術雑誌掲載論文等 |
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