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Title: Dynamic changes of serum microRNA-122-5p through therapeutic courses indicates amelioration of acute liver injury accompanied by acute cardiac decompensation
Authors: Koyama, Satoshi
Kuragaichi, Takashi
Sato, Yukihito
Kuwabara, Yasuhide
Usami, Shunsuke
Horie, Takahiro  kyouindb  KAKEN_id
Baba, Osamu
Hakuno, Daihiko
Nakashima, Yasuhiro  kyouindb  KAKEN_id
Nishino, Tomohiro  kyouindb  KAKEN_id
Nishiga, Masataka
Nakao, Tetsushi
Arai, Hidenori
Kimura, Takeshi  kyouindb  KAKEN_id
Ono, Koh
Author's alias: 桑原, 康秀
堀江, 貴裕
西野, 共達
木村, 剛
尾野, 亘
Keywords: Acute heart failure
Biomarker
Liver injury
MicroRNA
miR-122-5p
Issue Date: May-2017
Publisher: Wiley-Blackwell
Journal title: ESC Heart Failure
Volume: 4
Issue: 2
Start page: 112
End page: 121
Abstract: Aims: Recent studies have shown that serum microRNA (miR) abundance is informative for the diagnosis or prognosis of heart failure. However, the dynamics and kinetics of miRs in acute heart failure are largely unknown. Serial measurement and analysis of serum miRs changes in individuals along their therapeutic course could reduce inter-individual variation and should detect potentially important serum miRs related to disease mechanisms. Based on this concept, we profiled serum miR signatures of blood samples that were obtained sequentially on the day of admission and on hospital Day 7. Methods and results: This prospective, observational study included 42 consecutive acute heart failure patients (74 ± 1 years old, 24 male). From admission to Day 7, most of the patients showed clinical improvement. In such a cohort, we detected several fluctuations of serum miRs by two distinct screening methods (quantitative PCR and high-throughput sequencing). One of these fluctuating serum miRs, miR-122-5p, decreased significantly from Day 1 to Day 7 [median arbitrary unit (1st:3rd quantile value); 4.62 [2.39:12.3] to 3.07 [1.67:5.39], P = 0.007]. This fluctuation was significantly correlated with changes in serum liver function markers (estimated coefficient and 95% confidence interval; vs change in aspartate aminotransferase 1.69, 0.890–2.484, P < 0.001 and r = 0.560, vs change in alanine aminotransferase 1.09, 0.406–1.771, P = 0.007 and r = 0.428). Conclusions: The serum miR signature of patients with acute heart failure might indicate the severity of the disease or patients' response to therapeutic intervention. Notably, serum miR-122-5p levels reflect liver damage in this condition.
Rights: © 2016 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
URI: http://hdl.handle.net/2433/226330
DOI(Published Version): 10.1002/ehf2.12123
PubMed ID: 28451447
Appears in Collections:Journal Articles

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