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Title: Clinical and radiographic comparison of influenza virus-associated pneumonia among three viral subtypes
Authors: Ishiguro, Takashi
Takayanagi, Noboru
Kanauchi, Tetsu
Uozumi, Ryuji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9546-9869 (unconfirmed)
Kawate, Eriko
Takaku, Yotaro
Kagiyama, Naho
Shimizu, Yoshihiko
Hoshi, Toshiko
Morita, Satoshi
Sugita, Yutaka
Author's alias: 魚住, 龍史
森田, 智視
Keywords: influenza
pneumonia
subtypes
computed tomography
Issue Date: 2016
Publisher: Japanese Society of Internal Medicine
Journal title: Internal Medicine
Volume: 55
Issue: 7
Start page: 731
End page: 737
Abstract: [Objective] Presently, the predominant subtypes of influenza viruses in the world, except for those in local epidemics, include influenza pandemic H1N1 2009 (pH1N1), H3N2, and B viruses. There are few reports on the differences in the clinical features, radiographic findings, treatment, and outcomes of influenza virus-associated pneumonia among these three viral subtypes. The purpose of this study was to investigate whether the clinical features, radiographic findings, treatment, and outcomes differ among the viral subtypes. [Methods] We retrospectively analyzed 96 patients with influenza virus-associated pneumonia whose viral subtypes were clarified. [Results] Patients with pH1N1 virus-associated pneumonia tended to be young. The frequency of primary viral pneumonia differed among the virus-associated pneumonia subtypes (pH1N1, 80%; H3N2, 26.5%; and B, 31%). Patients with pH1N1 virus-associated pneumonia more frequently showed bilateral ground-glass opacities (GGOs), which affected more lobes than in patients with H3N2 and B virus-associated pneumonia. However, patients with H3N2 virus-associated pneumonia showed a higher frequency of consolidation and diffuse bronchial wall thickening than did the patients with pH1N1 virus-associated pneumonia. The severity and mortality did not differ among the three pneumonia subtypes. [Conclusion] In the patients who developed influenza virus-associated pneumonia, those with pH1N1 virus-associated pneumonia frequently developed primary viral pneumonia resulting in bilateral and broad areas of GGOs on imaging, whereas patients with H3N2 virus-associated pneumonia frequently showed consolidation and diffuse bronchial wall thickening on pulmonary imaging.
Rights: © 2016 The Japanese Society of Internal Medicine
The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/226549
DOI(Published Version): 10.2169/internalmedicine.55.5227
PubMed ID: 27041156
Appears in Collections:Journal Articles

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