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タイトル: | Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction |
著者: | Yang, Jihyeon Kim, Chu-Sook Tu, Thai Kim, Min-Seon Goto, Tsuyoshi https://orcid.org/0000-0003-1283-147X (unconfirmed) Kawada, Teruo Choi, Myung-Sook Park, Taesun Sung, Mi-Kyung Yun, Jong Choe, Suck-Young Lee, Jee Joe, Yeonsoo Choi, Hye-Seon Back, Sung Chung, Hun Yu, Rina |
著者名の別形: | 後藤, 剛 河田, 照雄 |
キーワード: | obesity inflammation hypothalamus microglia quercetin |
発行日: | 23-Jun-2017 |
出版者: | MDPI AG |
誌名: | Nutrients |
巻: | 9 |
号: | 7 |
論文番号: | 650 |
抄録: | Obesity-induced hypothalamic inflammation is characterized by activation of microglia, which are resident macrophages of the central nervous system, and is implicated in the derangement of energy homeostasis, metabolic complications, and neurodegenerative diseases. Quercetin, a naturally occurring flavonoid, is known to protect against oxidative stress and inflammation-related metabolic complications. Here, we demonstrate that quercetin reduces obesity-induced hypothalamic inflammation by inhibiting microglia-mediated inflammatory responses, and the beneficial action of quercetin is associated with heme oxygenase (HO-1) induction. Quercetin markedly reduced the production of inflammatory mediators (monocyte chemoattractant protein (MCP)-1, interleukin (IL-6), IL-1β, nitric oxide) by microglia stimulated with saturated fatty acid palmitate and/or lipid-laden microglia-conditioned medium. Quercetin also upregulated the expression of HO-1 in palmitate-treated lipid-laden microglia, and the actions of quercetin against microglia activation accompanied by IκBα degradation were abolished by a HO-1 inhibitor. Moreover, quercetin supplementation reduced the levels of inflammatory cytokines and microglia activation markers in the hypothalamus of high fat diet (HFD)-fed obese mice, which was accompanied by upregulation of HO-1. These findings indicate that quercetin suppresses microglia-mediated inflammatory responses via the induction of HO-1, and hence protects against obesity-induced hypothalamic inflammation. |
著作権等: | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). |
URI: | http://hdl.handle.net/2433/226659 |
DOI(出版社版): | 10.3390/nu9070650 |
PubMed ID: | 28644409 |
出現コレクション: | 学術雑誌掲載論文等 |
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