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タイトル: | UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage–specific manner |
著者: | Ishikawa, Tokiro https://orcid.org/0000-0003-1718-6764 (unconfirmed) Toyama, Takuya Nakamura, Yuki Tamada, Kentaro Shimizu, Hitomi Ninagawa, Satoshi Okada, Tetsuya https://orcid.org/0000-0002-2513-1301 (unconfirmed) Kamei, Yasuhiro Ishikawa-Fujiwara, Tomoko Todo, Takeshi Aoyama, Eriko Takigawa, Masaharu Harada, Akihiro Mori, Kazutoshi |
著者名の別形: | 石川, 時郎 遠山, 拓也 中村, 有貴 玉田, 健太郎 清水, 瞳 蜷川, 暁 岡田, 徹也 森, 和俊 |
キーワード: | Development Protein Homeostasis |
発行日: | 5-Jun-2017 |
出版者: | Rockefeller University Press |
誌名: | The Journal of Cell Biology |
巻: | 216 |
号: | 6 |
開始ページ: | 1761 |
終了ページ: | 1774 |
抄録: | The unfolded protein response (UPR) handles unfolded/misfolded proteins accumulated in the endoplasmic reticulum (ER). However, it is unclear how vertebrates correctly use the total of ten UPR transducers. We have found that ER stress occurs physiologically during early embryonic development in medaka fish and that the smooth alignment of notochord cells requires ATF6 as a UPR transducer, which induces ER chaperones for folding of type VIII (short-chain) collagen. After secretion of hedgehog for tissue patterning, notochord cells differentiate into sheath cells, which synthesize type II collagen. In this study, we show that this vacuolization step requires both ATF6 and BBF2H7 as UPR transducers and that BBF2H7 regulates a complete set of genes (Sec23/24/13/31, Tango1, Sedlin, and KLHL12) essential for the enlargement of COPII vesicles to accommodate long-chain collagen for export, leading to the formation of the perinotochordal basement membrane. Thus, the most appropriate UPR transducer is activated to cope with the differing physiological ER stresses of different content types depending on developmental stage. |
著作権等: | © 2017 Ishikawa et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
URI: | http://hdl.handle.net/2433/227005 |
DOI(出版社版): | 10.1083/jcb.201609100 |
PubMed ID: | 28500182 |
出現コレクション: | 学術雑誌掲載論文等 |
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