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dc.contributor.author | Muramatsu, Daisuke | en |
dc.contributor.author | Kimura, Hiroshi | en |
dc.contributor.author | Kotoshiba, Kaoru | en |
dc.contributor.author | Tachibana, Makoto | en |
dc.contributor.author | Shinkai, Yoichi | en |
dc.contributor.alternative | 村松, 大輔 | ja |
dc.contributor.alternative | 立花, 誠 | ja |
dc.date.accessioned | 2017-09-28T01:09:29Z | - |
dc.date.available | 2017-09-28T01:09:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0386-7196 | - |
dc.identifier.uri | http://hdl.handle.net/2433/227293 | - |
dc.description.abstract | Pericentric regions form epigenetically organized, silent heterochromatin structures that accumulate histone H3 lysine 9 tri-methylation (H3K9me3) and heterochromatin protein 1 (HP1), a methylated H3K9-binding protein. At pericentric regions, Suv39h is the major enzyme that generates H3K9me3. Suv39h also interacts directly with HP1. However, the importance of HP1 interaction for Suv39h-mediated H3K9me3 formation at the pericentromere is not well characterized. To address this question, we introduced HP1 binding-defective, N-terminally truncated mouse Suv39h1 (ΔN) into Suv39h-deficient cells. Pericentric H3K9me3-positive cells were not detected by endogenous-level expression of ΔN. Notably, ΔN could induce pericentric accumulation of H3K9me3 as wild type Suv39h1 did if it was overexpressed. These findings demonstrate that the N-terminal region of Suv39h1, presumably via HP1–Suv39h1 interaction, is required for Suv39h1-mediated pericentric H3K9me3 formation, but can be overridden if Suv39h1 is overproduced, indicating that Suv39h1-mediated heterochromatin formation is controlled by multiple modules, including HP1. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Japan Society for Cell Biology | en |
dc.publisher.alternative | 日本細胞生物学会 | ja |
dc.rights | © 2016 by Japan Society for Cell Biology | en |
dc.rights | Authors retain the copyright in their work and grant the journal a license to publish. Users have certain rights to share, distribute and re-use published content under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) license. | en |
dc.subject | H3K9 methylation | en |
dc.subject | HP1 | en |
dc.subject | major satellite repeats | en |
dc.subject | Suv39h | en |
dc.title | Pericentric H3K9me3 Formation by HP1 Interaction-defective Histone Methyltransferase Suv39h1 | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cell Structure and Function | en |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 145 | - |
dc.identifier.epage | 152 | - |
dc.relation.doi | 10.1247/csf.16013 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 27733730 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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