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タイトル: | Mild hyperbaric oxygen inhibits growth-related decrease in muscle oxidative capacity of rats with metabolic syndrome |
著者: | Takemura, Ai Ishihara, Akihiko |
著者名の別形: | 石原, 昭彦 |
キーワード: | Blood glucose Muscle fiber Oxidative metabolism Pgc-1α mRNA Soleus muscle |
発行日: | 1-Jan-2017 |
出版者: | Japan Atherosclerosis Society |
誌名: | Journal of Atherosclerosis and Thrombosis |
巻: | 24 |
号: | 1 |
開始ページ: | 26 |
終了ページ: | 38 |
抄録: | Aim: We examined the effects of mild hyperbaric oxygen on the properties of the soleus muscle in rats with metabolic syndrome. Methods: Five-week-old metabolic syndrome (SHR/NDmcr-cp, cp/cp) rats were divided into normobaric (CP) and mild hyperbaric oxygen (CP-H) groups (n=5/group). In addition, 5-week-old Wistar rats were assigned as the normobaric control (WR) group (n= 5). The CP-H group was exposed to 1.25 atmospheres absolute with 36% oxygen for 3 h daily for 16 weeks. Succinate dehydrogenase (SDH) activity and mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α (Pgc-1α) in the soleus muscle were examined. The fiber type composition, cross-sectional areas, and SDH staining intensity in the soleus muscle were also examined. Results: The CP-H group showed lower fasting and nonfasting blood glucose, glycated hemoglobin, total cholesterol, triglyceride, insulin, and systolic blood pressure levels; higher adiponectin levels; and higher SDH activity and mRNA levels of Pgc-1α in the muscle than the CP group. Compared with the CP group, the CP-H group had a lower percentage of type I fibers and observed type II A fibers in the muscle. The CP-H group also had higher SDH staining intensity of type I and type II C fibers in the muscle than the CP group. No differences in these values were observed in the muscles of the WR and CP-H groups. Conclusion: Mild hyperbaric oxygen inhibited growth-related increase in blood glucose levels and decrease in muscle oxidative capacity of rats with metabolic syndrome because of improved oxidative metabolism. |
著作権等: | © 2017 Japan Atherosclerosis Society. This article is applied Creative Commons License (Creative Commons Attribution (CC BY) license, Creative Commons Attribution Non-Commercial (CC BY-NC) license and Creative Commons Attribution Non-Commercial-NoDerivs License (CC BY-NC-ND) etc.) by the publisher. |
URI: | http://hdl.handle.net/2433/227680 |
DOI(出版社版): | 10.5551/jat.34686 |
PubMed ID: | 27237220 |
出現コレクション: | 学術雑誌掲載論文等 |
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