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dc.contributor.author | Nagami, Shinsuke | en |
dc.contributor.author | Oku, Yoshitaka | en |
dc.contributor.author | Yagi, Naomi | en |
dc.contributor.author | Sato, Susumu | en |
dc.contributor.author | Uozumi, Ryuji | en |
dc.contributor.author | Morita, Satoshi | en |
dc.contributor.author | Yamagata, Yoshie | en |
dc.contributor.author | Kayashita, Jun | en |
dc.contributor.author | Tanimura, Kazuya | en |
dc.contributor.author | Sato, Atsuyasu | en |
dc.contributor.author | Takahashi, Ryosuke | en |
dc.contributor.author | Muro, Shigeo | en |
dc.contributor.alternative | 永見, 慎輔 | ja |
dc.contributor.alternative | 八木, 直美 | ja |
dc.contributor.alternative | 佐藤, 晋 | ja |
dc.contributor.alternative | 魚住, 龍史 | ja |
dc.contributor.alternative | 森田, 智視 | ja |
dc.contributor.alternative | 谷村, 和哉 | ja |
dc.contributor.alternative | 佐藤, 篤靖 | ja |
dc.contributor.alternative | 髙橋, 良輔 | ja |
dc.contributor.alternative | 室, 繁郎 | ja |
dc.date.accessioned | 2017-10-25T03:11:53Z | - |
dc.date.available | 2017-10-25T03:11:53Z | - |
dc.date.issued | 2017-06-01 | - |
dc.identifier.issn | 2052-4439 | - |
dc.identifier.uri | http://hdl.handle.net/2433/227707 | - |
dc.description.abstract | [Introduction] Impaired coordination between breathing and swallowing (breathing–swallowing discoordination) may be a significant risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). We examined breathing–swallowing discoordination in patients with COPD using a noninvasive and quantitative technique and determined its association with COPD exacerbation. [Methods] We recruited 65 stable outpatients with COPD who were enrolled in our prospective observational cohort study and did not manifest an apparent swallowing disorder. COPD exacerbation was monitored for 1 year before and 1 year after recruitment. Swallowing during inspiration (the I-SW pattern) and swallowing immediately followed by inspiration (the SW-I pattern) were identified. [Results] The mean frequency of the I-SW and/or SW-I patterns (I-SW/SW-I rate) was 21.5%±25.5%. During the 2-year observation period, 48 exacerbation incidents (25 patients) were identified. The I-SW/SW-I rate was significantly associated with the frequency of exacerbation. During the year following recruitment, patients with a higher I-SW/SW-I frequency using thicker test foods exhibited a significantly higher probability of future exacerbations (p=0.002, log-rank test). [Conclusions] Breathing–swallowing discoordination is strongly associated with frequent exacerbations of COPD. Strategies that identify and improve breathing– swallowing coordination may be a new therapeutic treatment for patients with COPD. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | en |
dc.rights | © Article author(s). This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. | en |
dc.title | Breathing–swallowing discoordination is associated with frequent exacerbations of COPD | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | BMJ Open Respiratory Research | en |
dc.identifier.volume | 4 | - |
dc.identifier.issue | 1 | - |
dc.relation.doi | 10.1136/bmjresp-2017-000202 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e000202 | - |
dc.identifier.pmid | 28883930 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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