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タイトル: Frontal theta activation during motor synchronization in autism
著者: Kawasaki, Masahiro
Kitajo, Keiichi
Fukao, Kenjiro
Murai, Toshiya
Yamaguchi, Yoko
Funabiki, Yasuko
著者名の別形: 川崎, 真弘
北城, 圭一
深尾, 憲二朗
村井, 俊哉
山口, 陽子
船曳, 康子
キーワード: Autism spectrum disorders
Cognitive neuroscience
発行日: 8-Nov-2017
出版者: Springer Nature
誌名: Scientific Reports
巻: 7
論文番号: 15034
抄録: Autism is characterized by two primary characteristics: deficits in social interaction and repetitive behavioral patterns. Because interpersonal communication is extremely complicated, its underlying brain mechanisms remain unclear. Here we showed that both characteristics can be explained by a unifying underlying mechanism related to difficulties with irregularities. To address the issues, we measured electroencephalographm during a cooperative tapping task, which required participants to tap a key alternately and synchronously with constant rhythmic a PC program, a variable rhythmic PC program, or a human partner. We found that people with autism had great difficulty synchronizing tapping behavior with others, and exhibited greater than normal theta-wave (6 Hz) activity in the frontal cortex during the task, especially when their partner behaved somewhat irregularly (i.e. a variable rhythmic PC program or a human partner). Importantly, the higher theta-wave activity was related to the severity of autism, not the performance on the task. This indicates that people with autism need to use intense cognition when trying to adapt to irregular behavior and can easily become overtaxed. Difficulty adapting to irregular behavior in others is likely related to their own tendencies for repetitive and regular behaviors. Thus, while the two characteristics of autism have been comprehended separately, our unifying theory makes understanding the condition and developing therapeutic strategies more tractable.
記述: 自閉スペクトラム症者のコミュニケーション障害に関する新たな視点 --最新の脳波技術を用いた科学的根拠による理解の促進--. 京都大学プレスリリース. 2017-11-10.
著作権等: © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/227866
DOI(出版社版): 10.1038/s41598-017-14508-4
関連リンク: http://www.kyoto-u.ac.jp/ja/research/research_results/2017/171108_1.html
出現コレクション:学術雑誌掲載論文等

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