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dc.contributor.author | Kasubuchi, Mayu | en |
dc.contributor.author | Watanabe, Keita | en |
dc.contributor.author | Hirano, Kanako | en |
dc.contributor.author | Inoue, Daisuke | en |
dc.contributor.author | Li, Xuan | en |
dc.contributor.author | Terasawa, Kazuya | en |
dc.contributor.author | Konishi, Morichika | en |
dc.contributor.author | Itoh, Nobuyuki | en |
dc.contributor.author | Kimura, Ikuo | en |
dc.contributor.alternative | 寺澤, 和哉 | ja |
dc.contributor.alternative | 伊藤, 信行 | ja |
dc.date.accessioned | 2017-11-16T05:04:39Z | - |
dc.date.available | 2017-11-16T05:04:39Z | - |
dc.date.issued | 2017-07-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2433/227903 | - |
dc.description.abstract | Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors. Progesterone affects cell proliferation and survival via non-genomic effects. In this process, membrane progesterone receptors (mPRα, mPRβ, mPRγ, mPRδ, and mPRε) were identified as putative G protein-coupled receptors (GPCRs) for progesterone. However, the structure, intracellular signaling, and physiological functions of these progesterone receptors are still unclear. Here, we identify a molecular mechanism by which progesterone promotes neurite outgrowth through mPRβ (Paqr8) activation. Mouse mPRβ mRNA was specifically expressed in the central nervous system. It has an incomplete GPCR topology, presenting 6 transmembrane domains and did not exhibit typical GPCR signaling. Progesterone-dependent neurite outgrowth was exhibited by the promotion of ERK phosphorylation via mPRβ, but not via other progesterone receptors such as progesterone membrane receptor 1 (PGRMC-1) and nuclear progesterone receptor in nerve growth factor-induced neuronal PC12 cells. These findings provide new insights of regarding the non-genomic action of progesterone in the central nervous system. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | © The Author(s) 2017 | en |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. | en |
dc.subject | Hormone receptors | en |
dc.subject | Steroid hormones | en |
dc.title | Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Scientific Reports | en |
dc.identifier.volume | 7 | - |
dc.relation.doi | 10.1038/s41598-017-05423-9 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 5168 | - |
dc.identifier.pmid | 28701790 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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