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タイトル: | Retinal Blood Flow Velocity Change in Parafoveal Capillary after Topical Tafluprost Treatment in Eyes with Primary Open-angle Glaucoma |
著者: | Iida, Yuto Akagi, Tadamichi Nakanishi, Hideo Ohashi Ikeda, Hanako Morooka, Satoshi Suda, Kenji https://orcid.org/0000-0003-1636-0898 (unconfirmed) Hasegawa, Tomoko Yokota, Satoshi Yoshikawa, Munemitsu Uji, Akihito Yoshimura, Nagahisa |
著者名の別形: | 飯田, 悠人 赤木, 忠道 中西, 秀雄 池田, 華子/ 諸岡, 諭 須田, 謙史 長谷川, 智子 横田, 聡 吉川, 宗光 宇治, 彰人 吉村, 長久 |
キーワード: | Optic nerve diseases Translational research |
発行日: | 10-Jul-2017 |
出版者: | Springer Nature |
誌名: | Scientific Reports |
巻: | 7 |
論文番号: | 5019 |
抄録: | Although ocular circulation at the retina and optic disc is known to be associated with the pathology of glaucoma, direct measurement of blood flow velocity has been difficult to obtain. This prospective observational study enrolled 11 consecutive patients with treatment-naïve primary open-angle glaucoma (POAG) and 11 healthy subjects, and the effects of topical tafluprost treatment on ocular circulation were examined at baseline and at 1, 4, and 12 weeks after initiating treatment with topical tafluprost on POAG patients using multiple modalities, which include adaptive optics scanning laser ophthalmoscopy (AOSLO). Baseline mean intraocular pressure (IOP) was significantly higher and mean parafoveal blood flow velocity (pBFV) was significantly lower in POAG eyes than in healthy eyes. Mean IOP was significantly decreased (1 week, −19.1%; 4 weeks, −17.7%; and 12 weeks, −23.5%; all P < 0.001) and mean pBFV was significantly increased from the baseline at all follow-up periods after initiating treatment (1 week, 14.9%, P = 0.007; 4 weeks, 21.3%, P < 0.001; and 12 weeks, 14.3%, P = 0.002). These results reveal that tafluprost may not only lower IOP but may also improve retinal circulation in POAG eyes and AOSLO may be useful to evaluate retinal circulatory change after treatment. |
著作権等: | © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
URI: | http://hdl.handle.net/2433/228122 |
DOI(出版社版): | 10.1038/s41598-017-05258-4 |
PubMed ID: | 28694501 |
出現コレクション: | 学術雑誌掲載論文等 |
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