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Title: Retinal Blood Flow Velocity Change in Parafoveal Capillary after Topical Tafluprost Treatment in Eyes with Primary Open-angle Glaucoma
Authors: Iida, Yuto
Akagi, Tadamichi
Nakanishi, Hideo
Ohashi Ikeda, Hanako
Morooka, Satoshi
Suda, Kenji  kyouindb  KAKEN_id  orcid (unconfirmed)
Hasegawa, Tomoko
Yokota, Satoshi
Yoshikawa, Munemitsu
Uji, Akihito
Yoshimura, Nagahisa
Author's alias: 飯田, 悠人
赤木, 忠道
中西, 秀雄
池田, 華子/ 諸岡, 諭
須田, 謙史
長谷川, 智子
横田, 聡
吉川, 宗光
宇治, 彰人
吉村, 長久
Keywords: Optic nerve diseases
Translational research
Issue Date: 10-Jul-2017
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 7
Thesis number: 5019
Abstract: Although ocular circulation at the retina and optic disc is known to be associated with the pathology of glaucoma, direct measurement of blood flow velocity has been difficult to obtain. This prospective observational study enrolled 11 consecutive patients with treatment-naïve primary open-angle glaucoma (POAG) and 11 healthy subjects, and the effects of topical tafluprost treatment on ocular circulation were examined at baseline and at 1, 4, and 12 weeks after initiating treatment with topical tafluprost on POAG patients using multiple modalities, which include adaptive optics scanning laser ophthalmoscopy (AOSLO). Baseline mean intraocular pressure (IOP) was significantly higher and mean parafoveal blood flow velocity (pBFV) was significantly lower in POAG eyes than in healthy eyes. Mean IOP was significantly decreased (1 week, −19.1%; 4 weeks, −17.7%; and 12 weeks, −23.5%; all P < 0.001) and mean pBFV was significantly increased from the baseline at all follow-up periods after initiating treatment (1 week, 14.9%, P = 0.007; 4 weeks, 21.3%, P < 0.001; and 12 weeks, 14.3%, P = 0.002). These results reveal that tafluprost may not only lower IOP but may also improve retinal circulation in POAG eyes and AOSLO may be useful to evaluate retinal circulatory change after treatment.
Rights: © The Author(s) 2017.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
DOI(Published Version): 10.1038/s41598-017-05258-4
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