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Title: Collaborative roles of Temporoparietal Junction and Dorsolateral Prefrontal Cortex in Different Types of Behavioural Flexibility
Authors: Tei, Shisei
Fujino, Junya
Kawada, Ryosaku
Jankowski, Kathryn F.
Kauppi, Jukka-Pekka
van den Bos, Wouter
Abe, Nobuhito  kyouindb  KAKEN_id  orcid (unconfirmed)
Sugihara, Genichi
Miyata, Jun  kyouindb  KAKEN_id
Murai, Toshiya
Takahashi, Hidehiko
Author's alias: 鄭, 志誠
藤野, 純也
川田, 良作
阿部, 修士
杉原, 玄一
宮田, 淳
村井, 俊哉
高橋, 英彦
Keywords: Decision
Social behaviour
Issue Date: 25-Jul-2017
Publisher: Springer Nature
Journal title: Scientific Reports
Volume: 7
Thesis number: 6415
Abstract: Behavioural flexibility is essential for everyday life. This involves shifting attention between different perspectives. Previous studies suggest that flexibility is mainly subserved by the dorsolateral prefrontal cortex (DLPFC). However, although rarely emphasized, the temporoparietal junction (TPJ) is frequently recruited during flexible behaviour. A crucial question is whether TPJ plays a role in different types of flexibility, compared to its limited role in perceptual flexibility. We hypothesized that TPJ activity during diverse flexibility tasks plays a common role in stimulus-driven attention-shifting, thereby contributing to different types of flexibility, and thus the collaboration between DLPFC and TPJ might serve as a more appropriate mechanism than DLPFC alone. We used fMRI to measure DLPFC/TPJ activity recruited during moral flexibility, and examined its effect on other domains of flexibility (economic/perceptual). Here, we show the additional, yet crucial role of TPJ: a combined DLPFC/TPJ activity predicted flexibility, regardless of domain. Different types of flexibility might rely on more basic attention-shifting, which highlights the behavioural significance of alternatives.
Rights: © The Author(s) 2017.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
DOI(Published Version): 10.1038/s41598-017-06662-6
PubMed ID: 28743978
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