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Title: Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury
Authors: Nakagawa, Hiroshi
Ninomiya, Taihei
Yamashita, Toshihide
Takada, Masahiko  kyouindb  KAKEN_id
Author's alias: 中川, 浩
二宮, 太平
山下, 俊英
高田, 昌彦
Keywords: corticospinal tract
manual dexterity
primates
repulsive guidance molecule-a
spinal cord injury
Issue Date: Feb-2019
Publisher: Oxford University Press (OUP)
Journal title: Cerebral Cortex
Volume: 29
Issue: 2
Start page: 561
End page: 572
Abstract: Axons in the mature mammalian central nervous system have only a limited capacity to grow/regenerate after injury, and spontaneous recovery of motor functions is therefore not greatly expected in spinal cord injury (SCI). To promote functional recovery after SCI, it is critical that corticospinal tract (CST) fibers reconnect properly with target spinal neurons through enhanced axonal growth/regeneration. Here, we applied antibody treatment against repulsive guidance molecule-a (RGMa) to a monkey model of SCI. We found that inhibition of upregulated RGMa around the lesioned site in the cervical cord resulted in recovery from impaired manual dexterity by accentuated penetration of CST fibers into laminae VII and IX, where spinal interneurons and motoneurons are located, respectively. Furthermore, pharmacological inactivation following intracortical microstimulation revealed that the contralesional, but not the ipsilesional, primary motor cortex was crucially involved in functional recovery at a late stage in our SCI model. The present data indicate that treatment with the neutralizing antibody against RGMa after SCI is a potential target for achieving restored manual dexterity in primates.
Description: 脊髄損傷後に指の器用さ回復、サルで抗体治療に成功. 京都大学プレスリリース. 2018-01-09.
Rights: This is a pre-copyedited, author-produced PDF of an article accepted for publication in 'Cerebral Cortex' following peer review. The version of record 'Hiroshi Nakagawa, Taihei Ninomiya, Toshihide Yamashita, Masahiko Takada. Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury. (2018)' is available online at: https://doi.org/10.1093/cercor/bhx338
The full-text file will be made open to the public on 5 January 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving'
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/228892
DOI(Published Version): 10.1093/cercor/bhx338
PubMed ID: 29315368
Related Link: http://www.kyoto-u.ac.jp/ja/research/research_results/2017/180105_1.html
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