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j.bbrc.2017.10.130.pdf | 510.96 kB | Adobe PDF | 見る/開く |
タイトル: | Supplementation of pancreatic digestive enzymes alters the composition of intestinal microbiota in mice |
著者: | Nishiyama, Hiroki Nagai, Tomoyuki Kudo, Masatoshi Okazaki, Yoshihisa Azuma, Yoshinao Watanabe, Tomohiro Goto, Susumu Ogata, Hiroyuki https://orcid.org/0000-0001-6594-377X (unconfirmed) Sakurai, Toshiharu |
著者名の別形: | 西山, 拓輝 緒方, 博之 |
キーワード: | Chronic pancreatitis Pancreatic exocrine insufficiency Pancreatic enzyme replacement therapy Pancrelipase Intestinal microbiota Akkermansia muciniphila |
発行日: | 1-Jan-2018 |
出版者: | Elsevier BV |
誌名: | Biochemical and Biophysical Research Communications |
巻: | 495 |
号: | 1 |
開始ページ: | 273 |
終了ページ: | 279 |
抄録: | Although pancreatic enzyme replacement therapy (PERT) is effective in the alleviation of pancreatic exocrine insufficiency (PEI)-related symptoms in patients with chronic pancreatitis, its mechanism of action is poorly understood. Recent studies suggest that the intestinal microbiota is associated with the pathogenesis of chronic pancreatitis. Therefore, we hypothesized that PERT exerts its effect by modifying the intestinal microbiota in addition to its presumed role in promoting fat and protein absorption. To explore the mechanism of action of PERT, we analyzed the intestinal microbiotas of two groups of mice treated with either pancrelipase or tap water by using 16S rRNA amplicon sequencing. The results revealed that the bacterial compositions of the pancrelipase-treated mice were significantly different from those of the control samples. Akkermansia muciniphila, a key beneficial bacterium in the intestinal tract, showed a higher relative abundance in the pancrelipase-treated samples than in the control samples. Lactobacillus reuteri, a widely used probiotic bacterium known to relieve intestinal inflammation, also showed a higher relative abundance in the pancrelipase-treated samples. These results suggested that PERT induces the colonization of beneficial bacteria, thereby contributing to the attenuation of PEI-associated symptoms in addition to improvement of the nutritional state. |
著作権等: | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ The full-text file will be made open to the public on 1 January 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving' This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/228894 |
DOI(出版社版): | 10.1016/j.bbrc.2017.10.130 |
PubMed ID: | 29106956 |
出現コレクション: | 学術雑誌掲載論文等 |
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