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Title: Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4
Authors: Shimba, Akihiro
Cui, Guangwei  kyouindb  KAKEN_id
Tani-ichi, Shizue
Ogawa, Makoto
Abe, Shinya
Okazaki, Fumie
Kitano, Satsuki
Miyachi, Hitoshi
Yamada, Hisakata
Hara, Takahiro  kyouindb  KAKEN_id
Yoshikai, Yasunobu
Nagasawa, Takashi
Schütz, Günther
Ikuta, Koichi  kyouindb  KAKEN_id
Author's alias: 榛葉, 旭恒
崔, 広為
谷一, 靖江
阿部, 真也
岡崎, 史恵
原, 崇裕
生田, 宏一
Keywords: Immunology
Immunology and Allergy
Infectious Diseases
Issue Date: 20-Feb-2018
Publisher: Elsevier BV
Journal title: Immunity
Volume: 48
Issue: 2
Start page: 286
End page: 298.e6
Abstract: Glucocorticoids are steroid hormones with strong anti-inflammatory and immunosuppressive effects that are produced in a diurnal fashion. Although glucocorticoids have the potential to induce interleukin-7 receptor (IL-7R) expression in T cells, whether they control T cell homeostasis and responses at physiological concentrations remains unclear. We found that glucocorticoid receptor signaling induces IL-7R expression in mouse T cells by binding to an enhancer of the IL-7Ra locus, with a peak at midnight and a trough at midday. This diurnal induction of IL-7R supported the survival of T cells and their redistribution between lymph nodes, spleen, and blood by controlling expression of the chemokine receptor CXCR4. In mice, T cell accumulation in the spleen at night enhanced immune responses against soluble antigens and systemic bacterial infection. Our results reveal the immunoenhancing role of glucocorticoids in adaptive immunity and provide insight into how immune function is regulated by the diurnal rhythm.
Description: ステロイドが免疫力を高める --免疫の新たな昼夜サイクルを解明--. 京都大学プレスリリース. 2018-01-24.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
The full-text file will be made open to the public on 20 February 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving'
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/229416
DOI(Published Version): 10.1016/j.immuni.2018.01.004
PubMed ID: 29396162
Related Link: http://www.kyoto-u.ac.jp/ja/research/research_results/2017/180124_1.html
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