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タイトル: | Generation of germ cells from pluripotent stem cells in mammals |
著者: | Hayashi, Masafumi Kawaguchi, Takamasa Durcova-Hills, Gabriela Imai, Hiroshi |
著者名の別形: | 林, 将文 今井, 裕 |
キーワード: | embryonic stem cells germ line induced pluripotent stem cells primordial germ cells specification |
発行日: | Apr-2018 |
出版者: | Wiley-Blackwell |
誌名: | Reproductive Medicine and Biology |
巻: | 17 |
号: | 2 |
開始ページ: | 107 |
終了ページ: | 114 |
抄録: | [Background]The germ cell lineage transmits genetic and epigenetic information to the next generation. Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been studied extensively. Recently, in vitro models of PGC induction have been established in the mouse. Many attempts are reported to enhance our understanding of PGC development in other mammals, including human. [Methods]Here, original and review articles that have been published on PubMed are reviewed in order to give an overview of the literature that is focused on PGC development, including the specification of in vivo and in vitro in mice, human, porcine, and bovine. [Results]Mammalian PGC development, in vivo and in vitro, have been studied primarily by using the mouse model as a template to study PGC specification in other mammals, including human, porcine, and bovine. [Conclusion]The growing body of published works reveals similarities, as well as differences, in PGC establishment in and between mouse and human. |
著作権等: | © 2017 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
URI: | http://hdl.handle.net/2433/229791 |
DOI(出版社版): | 10.1002/rmb2.12077 |
PubMed ID: | 29692667 |
出現コレクション: | 学術雑誌掲載論文等 |
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