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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.stemcr.2018.01.032.pdf | 7.33 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
| DCフィールド | 値 | 言語 |
|---|---|---|
| dc.contributor.author | Iraha, Satoshi | en |
| dc.contributor.author | Tu, Hung-Ya | en |
| dc.contributor.author | Yamasaki, Suguru | en |
| dc.contributor.author | Kagawa, Takahiro | en |
| dc.contributor.author | Goto, Motohito | en |
| dc.contributor.author | Takahashi, Riichi | en |
| dc.contributor.author | Watanabe, Takehito | en |
| dc.contributor.author | Sugita, Sunao | en |
| dc.contributor.author | Yonemura, Shigenobu | en |
| dc.contributor.author | Sunagawa, Genshiro A. | en |
| dc.contributor.author | Matsuyama, Take | en |
| dc.contributor.author | Fujii, Momo | en |
| dc.contributor.author | Kuwahara, Atsushi | en |
| dc.contributor.author | Kishino, Akiyoshi | en |
| dc.contributor.author | Koide, Naoshi | en |
| dc.contributor.author | Eiraku, Mototsugu | en |
| dc.contributor.author | Tanihara, Hidenobu | en |
| dc.contributor.author | Takahashi, Masayo | en |
| dc.contributor.author | Mandai, Michiko | en |
| dc.date.accessioned | 2018-04-03T06:54:32Z | - |
| dc.date.available | 2018-04-03T06:54:32Z | - |
| dc.date.issued | 2018-03-13 | - |
| dc.identifier.issn | 2213-6711 | - |
| dc.identifier.uri | http://hdl.handle.net/2433/230369 | - |
| dc.description.abstract | Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies. Here, we established two mouse models of end-stage retinal degeneration with immunodeficiency, NOG-rd1-2J and NOG-rd10, and characterized disease progress and immunodeficient status. We also transplanted human ESC-derived retinal sheets into NOG-rd1-2J and confirmed their long-term survival and maturation of the structured graft photoreceptor layer, without rejection or tumorigenesis. We recorded light responses from the host ganglion cells using a multi-electrode array system; this result was consistent with whole-mount immunostaining suggestive of host-graft synapse formation at the responding sites. This study demonstrates an application of our mouse models and provides a proof of concept for the clinical use of human ESC-derived retinal sheets. | en |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | Elsevier BV | en |
| dc.rights | © 2018 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
| dc.subject | Developmental Biology | en |
| dc.subject | Genetics | en |
| dc.subject | Cell Biology | en |
| dc.subject | Biochemistry | en |
| dc.title | Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation | en |
| dc.type | journal article | - |
| dc.type.niitype | Journal Article | - |
| dc.identifier.jtitle | Stem Cell Reports | en |
| dc.identifier.volume | 10 | - |
| dc.identifier.spage | 1059 | - |
| dc.identifier.epage | 1074 | - |
| dc.relation.doi | 10.1016/j.stemcr.2018.01.032 | - |
| dc.textversion | publisher | - |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN・Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University・Application Biology and Regenerative Medicine, Graduate School of Medicine, Kyoto University | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN・Regenerative and Cellular Medicine Office, Sumitomo Dainippon Pharma Co., Ltd. | en |
| dc.address | Central Institute for Experimental Animals, Animal Resources and Technical Research Center | en |
| dc.address | Central Institute for Experimental Animals, Animal Resources and Technical Research Center | en |
| dc.address | Central Institute for Experimental Animals, Animal Resources and Technical Research Center | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN | en |
| dc.address | Ultrastructural Research Team, RIKEN Center for Life Science Technologies.・Department of Cell Biology, Tokushima University Graduate School of Medical Science | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN | en |
| dc.address | Regenerative and Cellular Medicine Office, Sumitomo Dainippon Pharma Co., Ltd. | en |
| dc.address | Regenerative and Cellular Medicine Office, Sumitomo Dainippon Pharma Co., Ltd. | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN | en |
| dc.address | Laboratory for in vitro Histogenesis, RIKEN Center for Developmental Biology | en |
| dc.address | Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN・Application Biology and Regenerative Medicine, Graduate School of Medicine, Kyoto University | en |
| dc.address | Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN・RIKEN Program for Drug Discovery and Medical Technology Platforms (DMP) | en |
| dc.identifier.pmid | 29503091 | - |
| dcterms.accessRights | open access | - |
| 出現コレクション: | 学術雑誌掲載論文等 | |
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