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dc.contributor.authorKoyasu, Sho
dc.contributor.authorKobayashi, Minoru
dc.contributor.authorGoto, Yoko
dc.contributor.authorHiraoka, Masahiro
dc.contributor.authorHarada, Hiroshi
dc.contributor.alternative子安, 翔
dc.contributor.alternative小林, 稔
dc.contributor.alternative後藤, 容子
dc.contributor.alternative平岡, 眞寛
dc.contributor.alternative原田, 浩
dc.date.accessioned2018-04-09T05:26:48Z-
dc.date.available2018-04-09T05:26:48Z-
dc.date.issued2018-03-03
dc.identifier.issn1347-9032
dc.identifier.urihttp://hdl.handle.net/2433/230435-
dc.description.abstractHypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 activity have been implicated in the pathogenesis of various diseases including malignant tumors and, thus, elucidating the molecular mechanisms underlying the activation of HIF‐1 is eagerly desired for the development of novel anti‐cancer strategies. The importance of oxygen‐dependent and ubiquitin‐mediated proteolysis of the regulatory subunit of HIF‐1 (HIF‐1α) was first reported in 1997. Since then, accumulating evidence has shown that HIF‐1α may become stable and active even under normoxic conditions; for example, when disease‐associated genetic and functional alterations in some genes trigger the aberrant activation of HIF‐1 regardless of oxygen conditions. We herein review the last two decades of knowledge, since 1997, on the regulatory mechanisms of HIF‐1 activity from conventional oxygen‐ and proteolysis‐dependent mechanisms to up‐to‐the‐minute information on cancer‐associated genetic and functional alteration‐mediated mechanisms.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBlackwell Publishing Ltd
dc.rights© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.subjectgene expression
dc.subjecthypoxia-inducible factor 1 (HIF-1)
dc.subjectmolecular mechanism
dc.subjecttumor hypoxia
dc.titleRegulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge
dc.type.niitypeJournal Article
dc.identifier.jtitleCancer Science
dc.identifier.volume109
dc.identifier.issue3
dc.identifier.spage560
dc.identifier.epage571
dc.relation.doi10.1111/cas.13483
dc.textversionpublisher
dc.addressLaboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation Biology Center, Kyoto University・Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
dc.addressLaboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation Biology Center, Kyoto University
dc.addressDepartment of Radiation Oncology and Image‐applied Therapy, Kyoto University Graduate School of Medicine
dc.addressDepartment of Radiation Oncology and Image‐applied Therapy, Kyoto University Graduate School of Medicine
dc.addressLaboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation Biology Center, Kyoto Universit・Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency (JST)
dc.identifier.pmid29285833
dc.identifier.kaken17J07699 / 16K15577 / 17K16433
Appears in Collections:Journal Articles

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