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j.ehpc.2017.10.004.pdf1.3 MBAdobe PDF見る/開く
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dc.contributor.authorToriu, Naoyaen
dc.contributor.authorHoshino, Junichien
dc.contributor.authorHasegawa, Eikoen
dc.contributor.authorSumida, Keiichien
dc.contributor.authorSuwabe, Tatsuyaen
dc.contributor.authorInenaga, Junichien
dc.contributor.authorKawada, Masahiroen
dc.contributor.authorUeno, Toshiharuen
dc.contributor.authorKikuchi, Koichien
dc.contributor.authorHayami, Norikoen
dc.contributor.authorSekine, Akinarien
dc.contributor.authorHiramatsu, Rikakoen
dc.contributor.authorYamanouchi, Masayukien
dc.contributor.authorSawa, Naokien
dc.contributor.authorTakaichi, Kenmeien
dc.contributor.authorOhashi, Kenichien
dc.contributor.authorUesugi, Norikoen
dc.contributor.authorFujii, Takeshien
dc.contributor.authorYanagita, Motokoen
dc.contributor.authorUbara, Yoshifumien
dc.contributor.alternative柳田, 素子ja
dc.date.accessioned2018-04-09T06:52:24Z-
dc.date.available2018-04-09T06:52:24Z-
dc.date.issued2018-03-
dc.identifier.issn2214-3300-
dc.identifier.urihttp://hdl.handle.net/2433/230438-
dc.description.abstractWe report a 33-year-old Japanese man diagnosed with mixed connective tissue disease (MCTD) who developed nephrotic proteinuria. Both speckled antinuclear antibody (ANA) and anti-U1 ribonucleoprotein (RNP) antibody were positive, but anti-double-stranded DNA (dsDNA) antibody and anti-Smith (Sm) antibody were negative, while complement levels were normal. Renal biopsy revealed membranous glomerulonephritis (MGN) with diffuse thickening of the glomerular basement membrane (GBM) plus spike and bubble formation. Immunofluorescence demonstrated granular deposits of IgG and C3 along the GBM. Analysis of IgG subclasses showed predominant deposition of IgG1 and IgG4, unlike typical lupus nephritis in which there is predominant deposition of IgG1, IgG2, IgG3, and C1q. Electron microscopy identified numerous large electron-dense deposits (EDD) of various types in the subepithelial region of the GBM, but there were no EDD localized in the mesangium or subendothelium. Based on these findings, MGN was considered to be closely related to MCTD in this patient.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier BVen
dc.rights© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en
dc.subjectMembranous glomerulonephritisen
dc.subjectMixed connective tissue diseaseen
dc.titleMembranous glomerulonephritis in a patient with anti-u1 ribonucleoprotein (RNP) antibody-positive mixed connective tissue disease: A case reporten
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleHuman Pathology: Case Reportsen
dc.identifier.volume11-
dc.identifier.spage43-
dc.identifier.epage46-
dc.relation.doi10.1016/j.ehpc.2017.10.004-
dc.textversionpublisher-
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressNephrology Center, Toranomon Hospitalen
dc.addressDepartment of Pathology, Toranomon Hospital・Department of Reumatology, Yokohama City Hospitalen
dc.addressDepartment of Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukubaen
dc.addressDepartment of Pathology, Toranomon Hospitalen
dc.addressDepartment of Nephrology, Kyoto University Graduate School of Medicineen
dc.addressNephrology Center, Toranomon Hospitalen
dcterms.accessRightsopen access-
dc.identifier.eissn2214-3300-
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