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journal.pntd.0006260.pdf | 1.39 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Sato, Marcello Otake | en |
dc.contributor.author | Sato, Megumi | en |
dc.contributor.author | Yanagida, Tetsuya | en |
dc.contributor.author | Waikagul, Jitra | en |
dc.contributor.author | Pongvongsa, Tiengkham | en |
dc.contributor.author | Sako, Yasuhito | en |
dc.contributor.author | Sanguankiat, Surapol | en |
dc.contributor.author | Yoonuan, Tipparayat | en |
dc.contributor.author | Kounnavang, Sengchanh | en |
dc.contributor.author | Kawai, Satoru | en |
dc.contributor.author | Ito, Akira | en |
dc.contributor.author | Okamoto, Munehiro | en |
dc.contributor.author | Moji, Kazuhiko | en |
dc.contributor.alternative | 岡本, 宗裕 | ja |
dc.date.accessioned | 2018-04-13T00:41:37Z | - |
dc.date.available | 2018-04-13T00:41:37Z | - |
dc.date.issued | 2018-02-08 | - |
dc.identifier.issn | 1935-2735 | - |
dc.identifier.uri | http://hdl.handle.net/2433/230550 | - |
dc.description.abstract | Most part of Southeast Asia is considered endemic for human-infecting Taenia tapeworms; Taenia solium, T. saginata, and T. asiatica. However, until now there was no report of the occurrence of human cases of T. asiatica in Lao PDR. This study, conducted in Savannakhet Province, Lao PDR, microscopically examined a total of 470 fecal samples by Kato Katz method and found 86% of people harboring at least one helminth. Hookworms were detected in 56% of the samples besides Opisthorchis like eggs (42%), Trichuris trichiura (27%), Ascaris spp. (14%), and Taenia spp. (4%) eggs. Serology for cysticercosis showed 6.8% positives with results varying from 3% to 14.3% in Ethnic School students and Kalouk Kao village respectively. Species-specific PCR targeting mitochondrial DNA (mtDNA) of 28 tapeworms, recovered from 16 patients, revealed T. solium (n = 2), T. saginata (n = 21), and T. asiatica (n = 5). Two patients were confirmed to be coinfected with T. saginata and T. asiatica, indicating the endemicity of the 3 human Taenia in Lao PDR. However, nucleotide sequencing of a nuclear DNA gene, DNA polymerase delta (pold) revealed that all the tapeworms identified as T. asiatica using mtDNA had T. saginata type allele at pold locus, demonstrating that they are not “pure T. asiatica” but the hybrid descendants between the two species, confirming the wide distribution of hybrids of T. saginata/ T. asiatica in Southeast Asia. The high prevalence of several helminthic NTDs in east Savannakhet area even with conventional control measures indicates the importance to establish wide and multifaceted health programs to sustainably improve the quality of life of the populations living in these communities. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | en |
dc.rights | © 2018 Sato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.title | Taenia solium, Taenia saginata, Taenia asiatica, their hybrids and other helminthic infections occurring in a neglected tropical diseases' highly endemic area in Lao PDR | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | PLOS Neglected Tropical Diseases | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 2 | - |
dc.relation.doi | 10.1371/journal.pntd.0006260 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e0006260 | - |
dc.address | Department of Tropical Medicine and Parasitology, Dokkyo Medical University | en |
dc.address | Graduate School of Health Sciences, Niigata University | en |
dc.address | Joint Faculty of Veterinary Medicine, Yamaguchi University | en |
dc.address | Department of Helminthology, Faculty of Tropical Medicine, Mahidol University | en |
dc.address | Station of Malariology, Parasitology, and Entomology of Savannakhet Province | en |
dc.address | Department of Parasitology, Asahikawa Medical University | en |
dc.address | Department of Helminthology, Faculty of Tropical Medicine, Mahidol University | en |
dc.address | Department of Helminthology, Faculty of Tropical Medicine, Mahidol University | en |
dc.address | National Institute of Public Health, Ministry of Health, Vientiane | en |
dc.address | Department of Tropical Medicine and Parasitology, Dokkyo Medical University | en |
dc.address | Department of Parasitology, Asahikawa Medical University | en |
dc.address | Primate Research Institute, Kyoto University | en |
dc.address | Graduate School of International Health Development, Nagasaki University | en |
dc.identifier.pmid | 29420601 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 24406011 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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