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タイトル: | Morphological Control of Microtubule-Encapsulating Giant Vesicles by Changing Hydrostatic Pressure |
著者: | Takiguchi, Kingo Hayashi, Masahito Kazayama, Yuki Toyota, Taro Harada, Yoshie Nishiyama, Masayoshi |
著者名の別形: | 西山, 雅祥 |
キーワード: | artificial cell model vesicle giant liposome microtubule hydrostatic pressure |
発行日: | 1-Mar-2018 |
出版者: | Pharmaceutical Society of Japan |
誌名: | Biological and Pharmaceutical Bulletin |
巻: | 41 |
号: | 3 |
開始ページ: | 288 |
終了ページ: | 293 |
抄録: | For the development of artificial cell-like machinery, liposomes encapsulating cytoskeletons have drawn much recent attention. However, there has been no report showing isothermally reversible morphological changes of liposomes containing cytoskeletons. We succeeded in reversibly changing the shape of cell-sized giant vesicles by controlling the polymerization/depolymerization state of cytoskeletal microtubules that were encapsulated in the vesicles using pressure changes. The result indicates that it is possible to manipulate artificial cell models composed of molecules such as lipids and proteins. The findings obtained in this study will be helpful in clarifying the details of cooperation between cytoskeletal dynamics and morphogenesis of biological membranes and in improving the design and construction of further advanced artificial cell-like machinery, such as drug-delivery systems. In addition, the experimental system used in this study can be applied to research to elucidate the adaptive strategy of living organisms to external stimuli and extreme conditions such as osmotic stress and high-pressure environments like the deep sea. |
著作権等: | ©2018 The Pharmaceutical Society of Japan |
URI: | http://hdl.handle.net/2433/230557 |
DOI(出版社版): | 10.1248/bpb.b17-00366 |
PubMed ID: | 29491204 |
出現コレクション: | 学術雑誌掲載論文等 |
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